Volume No. :   1

Issue No. :  1

Year :  2009

ISSN Print :  0975-4393

ISSN Online :  2349-2988


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Design and Characterization of Albumin-Chitosan Microspheres of Aceclofenac for Sustained Release



Address:   Sachin R Patil*1, Swati Patil4 ,Ravi Kumar1, MB Patil2 and Mahesh S Paschapur3
1Dept. of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, India.
2Dept. of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, India.
3Dept. of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, India.
4Department of Pharmacognosy, Principal KM Kundnani college of Pharmacy, Cuffe Parade, Mumbai
Corresponding Author:
DOI No:

ABSTRACT:
The present study deals with the formulation and characterization of cross linked chitosan/ albumin microspheres containing an NSAID drug Aceclofenac. The microspheres were prepared by suspension cross linking method using gluteraldehyde as a cross linking agent of the polymer matrix. Total eight formulation batches (F1 to F8) were formulated using chitosan/albumin alone and in combinations. The formulations were subjected to various evaluation parameters like % practical yield, entrapment efficiency, particle size distribution, swelling ratio, In vitro release and stability studies. Perfectly spherical cross linked microspheres loaded with aceclofenac were obtained in the size range of 50 – 500 µm. The % practical yield, entrapment efficiency, particle size, swelling ratio were increased with increased concentration of polymer used. The release of aceclofenac was influenced by polymer concentration and size of microspheres. The stability studies of formulation showed 4°C is suitable temperature for storage.
KEYWORDS:
Cross linked microspheres, Controlled release, Chitosan, Albumin, aceclofenac.
Cite:
Sachin R Patil, Swati Patil ,Ravi Kumar, MB Patil, Mahesh S Paschapur. Design and Characterization of Albumin-Chitosan Microspheres of Aceclofenac for Sustained Release. Research J. Science and Tech. 2009; 1(1): 35-38 .
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