Volume No. :   1

Issue No. :  1

Year :  2009

ISSN Print :  0975-4393

ISSN Online :  2349-2988


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Formulation and Evaluation of Captopril Fast Dissolving Tablets by WOW Tab and Effervescent Technologies



Address:   Ravi Kumar*1, Swati Patil4, MB Patil2, Mahesh S Paschapur3 and Sachin R Patil1
1Dept. of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, India.
2Dept. of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, India.
3Dept. of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, India.
4Department of Pharmacognosy, Principal KM Kundnani college of Pharmacy, Cuffe Parade, Mumbai.
Corresponding Author:
DOI No:

ABSTRACT:
Fast dissolving tablets of Captopril were prepared by Wow tab and Effervescent technologies. In this study our aim was to provide the tablet that quickly disintegrates or dissolves upon contact with saliva and also to provide a good mouth feel. The excipients used in both the technologies not only aid fast disintegration of tablets, but also mask the slight bitter taste of drug. All the prepared formulations were evaluated for thickness, hardness, friability, weight variation, drug content, and disintegration time and drug dissolution. Tablets from Wow tab and Effervescent technologies have shown 94 and 96% of the drug release at the end of 10 min respectively. Study has shown that 8:6 ratio of sodium bicarbonate and citric acid in the Captopril fast dissolving tablets gave good soothing and excellent mouth feel. Tablet prepared by Wow tab technology, formulation W5 and W6 using low moldability saccharide (lactose and mannitol) showed rapid disintegration and released about 92 and 96% drug respectively. Study concluded that fast dissolving tablets of Captopril could be prepared successfully by above mentioned methods. Tablets imparted patient benefits and increased consumer satisfaction, despite the different mechanisms involved in these techniques.
KEYWORDS:
Fast-dissolving tablets, Captopril, ACE inhibitor, oral cavity, In vitro dissolution.
Cite:
Ravi Kumar, Swati Patil, MB Patil, Mahesh S Paschapur, Sachin R Patil. Formulation and Evaluation of Captopril Fast Dissolving Tablets by WOW Tab and Effervescent Technologies. Research J. Science and Tech. 2009; 1(1): 29-32 .
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