Volume No. :   4

Issue No. :  6

Year :  2012

ISSN Print :  0975-4393

ISSN Online :  2349-2988


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Synthesis, Characterization and Biological Activity of Coumarin Derivatives

Address:   Kavitha K.*, Bindu Sree K., Jaya Preethi P., Pavan Kumar K., Rajvel R., Sivakumar T.
Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Erode, Tamil Nadu, India.
*Corresponding Author:

The coumarin-3-carboxylate prepared by known Knovengeal condensation. The coumarin-3-carbohydrazide prepared by reaction between formed carboxylate derivative with Hydrazine hydrate. The condensation of coumarin-3-carbohydrazide (CD-3) with phenylisothiocynate gives coumarin-3-carbo-N-phenylthiosemicarbazide (CD-4). The cyclization of CD-4 under different reaction conditions gives 1, 3, 4-oxadiazole, 1,3,4-thiadiazole, 1,2,4-triazole, thiazolidinone and thiopyrimidone. The synthesized compounds were charectarized by spectral analysis (IR, 1HNMR, Mass). All the compounds were screened for their Anti-inflammatory, Analgesic and Antituberculosis activity. The disc diffusion method was used for Antituberculosis activity. The MIC was determined by the micro broth dilution method using Mueller-Hinton broth. The Analgesic activity was performed by Acetic acid induced method. The Anti-inflammatory activity was performed by Carrageenan induced paw edema method.
Knovengeal condensation, phenylisothiocynate, characterization, anti tuberculosis activity.
Kavitha K, Bindu Sree K, Jaya Preethi P, Pavan Kumar K, Rajvel R, Sivakumar T.. Synthesis, Characterization and Biological Activity of Coumarin Derivatives. Research J. Science and Tech. 2012; 4(6): 252-257.
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