Volume No. :   4

Issue No. :  6

Year :  2012

ISSN Print :  0975-4393

ISSN Online :  2349-2988


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Synthesis, Characterization and Biological Activity of Coumarin Derivatives



Address:   Kavitha K.*, Bindu Sree K., Jaya Preethi P., Pavan Kumar K., Rajvel R., Sivakumar T.
Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Erode, Tamil Nadu, India.
*Corresponding Author:
DOI No:

ABSTRACT:
The coumarin-3-carboxylate prepared by known Knovengeal condensation. The coumarin-3-carbohydrazide prepared by reaction between formed carboxylate derivative with Hydrazine hydrate. The condensation of coumarin-3-carbohydrazide (CD-3) with phenylisothiocynate gives coumarin-3-carbo-N-phenylthiosemicarbazide (CD-4). The cyclization of CD-4 under different reaction conditions gives 1, 3, 4-oxadiazole, 1,3,4-thiadiazole, 1,2,4-triazole, thiazolidinone and thiopyrimidone. The synthesized compounds were charectarized by spectral analysis (IR, 1HNMR, Mass). All the compounds were screened for their Anti-inflammatory, Analgesic and Antituberculosis activity. The disc diffusion method was used for Antituberculosis activity. The MIC was determined by the micro broth dilution method using Mueller-Hinton broth. The Analgesic activity was performed by Acetic acid induced method. The Anti-inflammatory activity was performed by Carrageenan induced paw edema method.
KEYWORDS:
Knovengeal condensation, phenylisothiocynate, characterization, anti tuberculosis activity.
Cite:
Kavitha K, Bindu Sree K, Jaya Preethi P, Pavan Kumar K, Rajvel R, Sivakumar T.. Synthesis, Characterization and Biological Activity of Coumarin Derivatives. Research J. Science and Tech. 2012; 4(6): 252-257.
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