Volume No. :   4

Issue No. :  6

Year :  2012

ISSN Print :  0975-4393

ISSN Online :  2349-2988


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Determination of Prochlorperazine Maleate and Pyridoxine Hydrochloride in Combined Tablet Dosage form by using first order derivative Spectrophotomeric method



Address:   G. B. Bhagwat1,2*, P. T. Sonawane2 and V. V. Bopinwar2
1Department of Pharmaceutical Chemistry, Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur 441 110 (M.S.), India.
2Department of Pharmaceutical Chemistry, Kasturi Shikshan Sanstha’s College of Pharmacy, Shikrapur, Pune 412 208 (M. S.), India
*Corresponding Author:
DOI No:

ABSTRACT:
A simple, accurate, economical and reproducible procedure for simultaneous estimation of Prochlorperazine Maleate and Pyridoxine Hydrochloride in their tablet dosage form is described. In this method 0.3M HCl was utilized as solvent. In first order derivative spectroscopic method, two wavelengths 252nm for prochlorperazine maleate (zero cross for pyridoxine hydrochloride) and 228.5nm for pyridoxine hydrochloride (zero cross for prochlorperazine maleate) were selected. Both drugs obey Beer-Lambert’s law in concentration range of 1-5 µg/ml (prochlorperazine maleate) and 5-25 µg/ml (pyridoxine hydrochloride) respectively in 0.3M HCl. The suggested method is validated by using ICH validation parameters like accuracy, precision, specificity, ruggdness and linearity. The results of recovery study were found to be within the prescribed limit of 98-102%. During the linearity study it was observed that absorbance values of Prochlorperazine Maleate and Pyridoxine Hydrochloride in marketed formulation were linear in the range of 80% to 120% of test concentration with R2 close to 1 for this method of analysis.
KEYWORDS:
Prochlorperazine Maleate, Pyridoxine Hydrochloride, first order derivative spectroscopic method
Cite:
G. B. Bhagwat, P. T. Sonawane, V. V. Bopinwar. Determination of Prochlorperazine Maleate and Pyridoxine Hydrochloride in Combined Tablet Dosage form by using first order derivative Spectrophotomeric method. Research J. Science and Tech. 2012; 4(6): 262-266 .
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