Volume No. :   8

Issue No. :  1

Year :  2016

ISSN Print :  0975-4393

ISSN Online :  2349-2988


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Spectrophotometric Method Development and Validation of Prazosin



Address:   Nikam Pooja1, Baokar Shrikrishna1*, Undare Santosh2, Patil R.N1
1Department of Pharmaceutical Analysis, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk), Tal- Baramati, Dist- Pune, Maharashtra, India 413115
2PG Department of Chemistry, Marathwada Shikshan Prasarak Mandal’s Balbhim Arts, Science and Commerce College, Beed, Maharashtra, India 431112.
*Corresponding Author
DOI No: 10.5958/2349-2988.2016.00001.2

ABSTRACT:
Prazosin Hydrochloride (PRZ) is an antihypertensive agent which is one of the leading marketed drugs in the world. A rapid, specific and economic UV spectrophotometrically method has been developed using methanol as a solvent to determine the PRZ content in bulk and pharmaceutical dosage formulations. At a pre-determined ?max of 2 nm, it was proved linear in the range of 1 - 5 µg/mL, and exhibited good correlation coefficient (R2=0.999) and excellent mean recovery. This method was successfully applied to the determination of PRZ content in one marketed brand from India and the results were in good agreement with the label claim. The method was validated statistically and by recovery studies for linearity, precision, accuracy, ruggedness, robustness, LOD and LOQ. The obtained results proved that this method can be employed for the routine analysis of PRZ in bulks as well as in the commercial formulations.
KEYWORDS:
UV-spectrophotometer, Prazosin, Antihypertensive agent.
Cite:
Nikam Pooja, Baokar Shrikrishna, Undare Santosh, Patil R.N. Spectrophotometric Method Development and Validation of Prazosin. Research J. Science and Tech. 8(1): Jan.– Mar. 2016; Page 01-04.
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