Volume No. :   8

Issue No. :  2

Year :  2016

ISSN Print :  0975-4393

ISSN Online :  2349-2988


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Buccal Drug Delivery System-A Novel Drug Delivery System



Address:   Debjit Bhowmik1*, K.P. Sampath Kumar2, Lokesh Deb3
1Himachal Institute of Pharmacy Education and Research Naudan Hamirpur, Himachal Pradesh
2Department of Pharmaceutical Sciences, Coimbatore Medical College, Coimbatore
3Medicinal Plants and Horticultural Resources Division, Institute of Bioresources and Sustainable Development. (IBSD), Department of Biotechnology, Government of India, Takylpat, Imphal, Manipur
*Corresponding Author
DOI No: 10.5958/2349-2988.2016.00012.7

ABSTRACT:
Buccal delivery is defined as drug administration through the mucosal membranes lining the cheeks (buccal mucosa).The main impediment to the use of many hydrophilic macromolecular drugs as potential therapeutic agents is their inadequate and erratic oral absorption. The future challenge of pharmaceutical scientists is to develop effective non-parenteral delivery of intact proteins and peptides to the systemic circulation. Based on our current understanding of biochemical and physiological aspects of absorption and metabolism of many biotechnologically- produced drugs, they cannot be delivered effectively through the conventional oral route. Because after oral administration many drugs are subjected to presystemic clearance extensive in liver, which often leads to a lack of significant correlation between membrane permeability, absorption, and bioavailability.
KEYWORDS:
Buccal delivery, bioadhesion bioavailability
Cite:
Debjit Bhowmik, K.P. Sampath Kumar, Lokesh Deb. Buccal Drug Delivery System-A Novel Drug Delivery System. Research J. Science and Tech. 2016; 8(2):90-98.
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