Volume No. :   10

Issue No. :  1

Year :  2018

ISSN Print :  0975-4393

ISSN Online :  2349-2988


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Novel Spectrophotometric Method for Determination of Non-Nucleoside Reverse Transcriptase Inhibitor in Bulk and Pharmaceutical Dosage Form



Address:   Ramya. B, Vinutha Kommineni*, Sridevi Pingali, M. Bhagavan Raju
Department of Pharmaceutical Analysis, Sri Venkateshwara College of Pharmacy, Madhapur, Hyderabad, India
*Corresponding Author
DOI No: 110.5958/2349-2988.2018.00004.9

ABSTRACT:
The aim of the present work is to develop new, simple, accurate, precise, sensitive, reproducible and cost effective UV spectrophotometric method for the determination of non-nucleotide reverse transcriptase inhibitor in bulk and pharmaceutical dosage form using Sodium nitroprusside. It exhibits absorption maximum at 445nm. The Beer’s law has been obeyed in the concentration range of 4-20µg/ml with the detection limits of 0.10µg/ml. The molar absorptivity and Sandell’s sensitivity of the method was reported. The proposed method was effectively applied to the analysis of the Rilpivirine in their tablet formulation. The assay was not interfered by common excipients guidelines.
KEYWORDS:
Spectrophotometric method, Rilpivirine, Sodium nitroprusside, Validation, Analysis.
Cite:
Ramya. B, Vinutha Kommineni, Sridevi Pingali, M. Bhagavan Raju. Novel Spectrophotometric Method for Determination of Non-Nucleoside Reverse Transcriptase Inhibitor in Bulk and Pharmaceutical Dosage Form. Research J. Science and Tech. 2018; 10(1):19-27
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