Volume No. :   10

Issue No. :  2

Year :  2018

ISSN Print :  0975-4393

ISSN Online :  2349-2988


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Gastro Retentive Drug Delivery Systems-a Novel Approaches of Controlled Drug Delivery Systems



Address:   Debjit Bhowmik*, Rishab Bhanot, Darsh Gautam, Parshuram Rai, K. P. Sampath Kumar
Himachal Institute of Pharmaceutical Education and Research, Nadaun, Hamirpur, H. P.
Department of Pharmacy, Coimbatore government medical college, Coimbatore
*Corresponding Author
DOI No: 10.5958/2349-2988.2018.00022.0

ABSTRACT:
Gastro-retentive drug delivery technology is designed to retain a drug in the upper gastrointestinal tract for a prolonged period of time to allow efficient absorption. This is important because almost 40% of all new drugs have poor bioavailability from the lower gastrointestinal tract. Gastric retention will provide advantages such as the delivery of drugs with narrow absorption windows in the small intestinal region. Also, longer residence time in the stomach could be advantageous for local action in the upper part of the small intestine, for example treatment of peptic ulcer disease. Furthermore, improved bioavailability is expected for drugs that are absorbed readily upon release in the GI tract. These drugs can be delivered ideally by slow release from the stomach. The application of our unique gastro-retentive technology include: Use with drugs targeting absorption in the upper segment of the small intestine, Use with drugs targeting absorption in just the stomach, Suitable for high drug loads, Use with a range of drugs, including poorly soluble molecules.
KEYWORDS:
Gastro-retentive drug delivery, Controlled drug delivery system, Gastric retention.
Cite:
Debjit Bhowmik, Rishab Bhanot, Darsh Gautam, Parshuram Rai, K. P. Sampath Kumar. Gastro Retentive Drug Delivery Systems-a Novel Approaches of Controlled Drug Delivery Systems. Research J. Science and Tech. 2018; 10(2): 145-156.
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