Volume No. :   10

Issue No. :  2

Year :  2018

ISSN Print :  0975-4393

ISSN Online :  2349-2988


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Studies on Synthesis of Aromatic Schiff Bases. Part-V. Evaluation of Antifungal Potential of Ketimines from 5-Chloro-2-hydroxy-4-methyl-acetophenone†



Address:   C. J. Patil1*, Manisha C. Patil2, Mrunmayee C. Patil3
1Smt. G. G. Khadse College, Muktainagar, Dist-Jalgaon-425 306, M.S., India
2Dr. A. G. D. Bendale Mahila College, Jalgaon-425 001, M.S., India
3Dept. of Pharma. Sci. and Tech., Nathalal Parekh Marg, Institute of Chemical Technology, Matunga, Mumbai-400 019, M.S., INDIA.
*Corresponding Author
DOI No: 10.5958/2349-2988.2018.00018.9

ABSTRACT:
The condensed reaction of aromatic ketone, 5-Chloro-2-hydroxy-4-methyl-acetophenone with aniline derivatives viz. 2,3-Dimethyl-aniline, 2,4-Dimethyl-aniline, 3,4-Dimethyl-aniline and 2,5-Dimethyl-aniline to yield a ketimines, CJ-1 to CJ-4. These were analyzed by employing the techniques such as thin layer chromatography(TLC) and UV-Vis spectra. After confirming their desired molecular studies, these novel ketimines were studied for their antifungal potential.
KEYWORDS:
Ketimines, 5-Chloro-2-hydroxy-4-methyl-acetophenone, D. S. Trap, substituted anilines, TLC and UV-Vis, molar extinction coefficients(εmax) and antifungal potential.
Cite:
C. J. Patil, Manisha C. Patil, Mrunmayee C. Patil. Studies on Synthesis of Aromatic Schiff Bases. Part-V. Evaluation of Antifungal Potential of Ketimines from 5-Chloro-2-hydroxy-4-methyl-acetophenone† . Research J. Science and Tech. 2018; 10(2):125-130.
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