Volume No. :   11

Issue No. :  1

Year :  2019

ISSN Print :  0975-4393

ISSN Online :  2349-2988


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Estimation of Almotriptan malate in tablets by sensitive Visible Spectrophotometric method



Address:   B. Kalyana Ramu1*, M. Syam Bab*2, U. Viplava Prasad2 P. Konda Babu3
1Department of Chemistry, Maharajah’s College (Aided and Autonomous), Vizianagaram-535002 (AP) India.
2Department of Organic Chemistry and Analysis of Foods Drugs and Water Laboratories, School of Chemistry, Andhra University, Visakhapatnam-530003, Andhra Pradesh (India)
3Department of Statistics, Maharajah’s College (Aided and Autonomous), Vizianagaram-535002 (AP) India.
*Corresponding Author
DOI No: 10.5958/2349-2988.2019.00012.3

ABSTRACT:
A simple, sensitive indirect visible spectrophotometric method has been developed for the estimation of almotriptan malate either in bulk or tablet dosage forms. The method is based on the oxidation of drug with excess N-Bromo succinimide and determining the unreacted NBS with reagents PMAP-SA by spectrophotometrically at 520nm Beer’s law obeyed in the concentration range of 4-20 µg/ml. No interference was observed from the usually existing additives in pharmaceutical formulations and the applicability of the method was examined by analyzing AXERT tablets containing AM. The statistical data indicates the accuracy, reproducibility and the precision of the proposed method.
KEYWORDS:
Determination, Beer’s Law, Charge- transfer complex formation, Spectrophotometer, Statistical analysis, Tablets.
Cite:
B. Kalyana Ramu, M. Syam Bab, U. Viplava Prasad, P. Konda Babu. Estimation of Almotriptan malate in tablets by sensitive Visible Spectrophotometric method. Research J. Science and Tech. 2019; 11(1):77-81.
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