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Research Journal of Science and Technology
ISSN: 2349-2988(Online), 0975-4393(Print)
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Simultaneous Estimation and Validation of Dapagliflozin and Saxagliptin in Bulk Drug and Dosage Form by RP-HPLC
Rahul K. Godge
Ganesh S. Shinde
Rahul K. Godge*, Ganesh S. Shinde, Shraddha Joshi
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, India
A simple, rapid, precise, accurate RP-HPLC method has been developed and validated to estimate Saxagliptin hydrochloride and Dapagliflozin in bulk and in dosage form. The samples were eluated Grace C18 (250mm x 4.6 ID, Particle size: 5micron with mobile phase Methanol: water (pH adjusted to 3 with potassium dihydrogen orthophosphate) (80:20) at wavelength 225nm. A good linear response was obtained in the range from 10-50µg/mL for Saxagliptin hydrochloride and Dapagliflozin. The method was quantitatively evaluated in terms of linearity, precision, accuracy (recovery), selectivity and robustness as per USP guideline.
Saxagliptin, Dapagliflozin, RP-HPLC.
Rahul K. Godge, Ganesh S. Shinde, Shraddha Joshi. Simultaneous Estimation and Validation of Dapagliflozin and Saxagliptin in Bulk Drug and Dosage Form by RP-HPLC. Research J. Science and Tech. 2019; 11(1):59-63.
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