Volume No. :   11

Issue No. :  1

Year :  2019

ISSN Print :  0975-4393

ISSN Online :  2349-2988


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Simultaneous Estimation and Validation of Dapagliflozin and Saxagliptin in Bulk Drug and Dosage Form by RP-HPLC



Address:   Rahul K. Godge*, Ganesh S. Shinde, Shraddha Joshi
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, India
*Corresponding Author
DOI No: 10.5958/2349-2988.2019.00008.1

ABSTRACT:
A simple, rapid, precise, accurate RP-HPLC method has been developed and validated to estimate Saxagliptin hydrochloride and Dapagliflozin in bulk and in dosage form. The samples were eluated Grace C18 (250mm x 4.6 ID, Particle size: 5micron with mobile phase Methanol: water (pH adjusted to 3 with potassium dihydrogen orthophosphate) (80:20) at wavelength 225nm. A good linear response was obtained in the range from 10-50µg/mL for Saxagliptin hydrochloride and Dapagliflozin. The method was quantitatively evaluated in terms of linearity, precision, accuracy (recovery), selectivity and robustness as per USP guideline.
KEYWORDS:
Saxagliptin, Dapagliflozin, RP-HPLC.
Cite:
Rahul K. Godge, Ganesh S. Shinde, Shraddha Joshi. Simultaneous Estimation and Validation of Dapagliflozin and Saxagliptin in Bulk Drug and Dosage Form by RP-HPLC. Research J. Science and Tech. 2019; 11(1):59-63.
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