Volume No. :   11

Issue No. :  1

Year :  2019

ISSN Print :  0975-4393

ISSN Online :  2349-2988


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In Vitro Antidiabetic activity of Ethanol and Aqueous leaf extracts of Azima tetracantha Lam



Address:   B. Edwin Jose1, Dr. P. Panneerselvam2
1Department of Pharmaceutical Chemistry, SSM College of Pharmacy, Erode.
2Department of Pharmaceutical Chemistry, Bharath Institute of Higher Education and Research, Chennai
*Corresponding Author
DOI No: 10.5958/2349-2988.2019.00009.3

ABSTRACT:
The present investigation includes the preliminary screening of phytochemicals and evaluation of an in vitro antidiabetic activity of Azima tetracantha LAM extracts. Plant material was sub¬jected to the extract preparation by soxhlet apparatus by using various solvents such as aqueous, ethanol, chloroform, petroleum ether. The various kinds of phytochemicals were detected and then in vitro antidiabetic activity of Azima tetracantha LAM ethanol and aqueous extracts were detected by using alpha amy¬lase and alpha glucosidase enzyme in an in vitro model. The study reveals the presence of phytochemicals such as carbohydrate, tannin, flavonoids, phenols etc., Among the various extracts the aqueous and ethanolic extracts which contains the large number of phytoconstituents. The Azima tetracantha LAM extracts has been successfully inhibited both the enzymes in an in vitro model. The aqueous extracts of Azima tetracantha LAM inhibited the alpha amylase and alpha glucosidase enzymes as 48.59% and 64.99% respectively. The ethanolic extract of Azima tetracantha LAM inhibited the alpha amylase and alpha glucosidase enzymes as 65.34% and 58.48% respectively. From the results obtained in the current studies, the Azima tetracantha LAM extracts have a prominent antidiabetic property in an in vitro model and further studies can be carried out in an in vivo model and the isolation of active compound from Azima tetracantha LAM extract is needed.
KEYWORDS:
Alpha amylase, Alpha glucosidase, Azima tetracantha LAM, Phytochemical.
Cite:
B. Edwin Jose, P. Panneerselvam. In Vitro Antidiabetic activity of Ethanol and Aqueous leaf extracts of Azima tetracantha Lam. Research J. Science and Tech. 2019; 11(1):64-68.
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