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Research Journal of Science and Technology
ISSN: 2349-2988(Online), 0975-4393(Print)
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Analytical Method Development and Validation of Rivaroxaban- A Review
Anuja Uddhav Deokar
Dr Suhas Siddheshwar
Sudarshan. B. Kakad
Anuja Uddhav Deokar1*, Dr Suhas Siddheshwar2, Sudarshan. B. Kakad3
1Research Scholar, M Pharmacy, Pravara Rural College of Pharmacy, Pravaranagar
2Assistant Professor, Pravara Rural College of Pharmacy, Pravaranagar
3Assistant Professor, Pravara Rural College of Pharmacy, Pravaranagar
Rivaroxaban is oxazolidine derivatives having anticoagulant activity. In literature few analytical methods are discussed for the estimation of Rivaroxaban. The objective of this study is to develop and validate RP-HPLC method for the qualitative estimation of the drug. In most of the methods, the isocratic elution was carried out by using Acetonitrile, water and buffer as a mobile phase. The wavelength was in between 245 to 252 nm. The flow rate was approximately 1.0 ml/min. the temperature set was ambient temperature. The developed methods were validated as per ICH guidelines and this methods were found to be specific, precise, sensitive and robustness.
Rivaroxaban, oxazolidine, RP-HPLC method, Anticoagulant, Validation. System suitability. Stability-indicating. Pharmaceutical dosage form, ICH.
Anuja Uddhav Deokar, Dr Suhas Siddheshwar, Sudarshan. B. Kakad. Analytical Method Development and Validation of Rivaroxaban- A Review. Research J. Science and Tech. 2020; 12(1):36-46.
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