Volume No. :   12

Issue No. :  1

Year :  2020

ISSN Print :  0975-4393

ISSN Online :  2349-2988


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Analytical Method Development and Validation of Rivaroxaban- A Review



Address:   Anuja Uddhav Deokar1*, Dr Suhas Siddheshwar2, Sudarshan. B. Kakad3
1Research Scholar, M Pharmacy, Pravara Rural College of Pharmacy, Pravaranagar
2Assistant Professor, Pravara Rural College of Pharmacy, Pravaranagar
3Assistant Professor, Pravara Rural College of Pharmacy, Pravaranagar
*Corresponding Author
DOI No: 10.5958/2349-2988.2020.00004.2

ABSTRACT:
Rivaroxaban is oxazolidine derivatives having anticoagulant activity. In literature few analytical methods are discussed for the estimation of Rivaroxaban. The objective of this study is to develop and validate RP-HPLC method for the qualitative estimation of the drug. In most of the methods, the isocratic elution was carried out by using Acetonitrile, water and buffer as a mobile phase. The wavelength was in between 245 to 252 nm. The flow rate was approximately 1.0 ml/min. the temperature set was ambient temperature. The developed methods were validated as per ICH guidelines and this methods were found to be specific, precise, sensitive and robustness.
KEYWORDS:
Rivaroxaban, oxazolidine, RP-HPLC method, Anticoagulant, Validation. System suitability. Stability-indicating. Pharmaceutical dosage form, ICH.
Cite:
Anuja Uddhav Deokar, Dr Suhas Siddheshwar, Sudarshan. B. Kakad. Analytical Method Development and Validation of Rivaroxaban- A Review. Research J. Science and Tech. 2020; 12(1):36-46.
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