Therapeutic potential of Hibiscusrosa sinensis - A Review

 

Mohini Shelke*, Shraddha Parjane, S. D Mankar, Dr. S. S. Siddheshwar

Pravara Rural College of Pharmacy, Pravaranagar A/P Loni - 413736, Tal - Rahata, Dist - Ahmednagar (M.S)

*Corresponding Author E-mail: sdmankar655@gmail.com

 

ABSTRACT:

Hibiscus sinensis is an annual/Perennial plant belongs to Malvaceae family commonly referred to as "roselle" famous for its medicinal value found world wide and native to West and East Africa, South-East Asia, Northeastern India. Roselle is cultivated in humid and warm climate. The plant consist phytoconstituents like malic, citric, tartaric, allo-hydroxycitric acid also reach in vitamin C, Vitamin A. Roselle is popular for it's therapeutic and nutritional value. Seeds, leaves, fruits and roots are utilized in herbal medicine for hair growth treatment. The Roselle, having various medically important compounds called photochemical, is documented for its nutritional and medicinal properties. Many parts of Roselle including seeds, leaves, fruits and roots are utilized in various foods also as in herbal medicine as a possible non-pharmacological treatment. In the treatment of various medical conditions, including several cardiovascular diseases, helmentic disease and cancer, different extracts from Roselle play an important role. Phytochemical research has reported that flavonoids, tannins, terpenoids, saponins, and alkaloids are the most bioactive compounds responsible for their medicinal effects. Experiments from recent studies have shown that different types of extracts from all Hibiscus. The components of rosa sinensis showed a good range of beneficial effects, such as hypotensive, anti-pyritic, anti-inflammatory, anti-cancer, antioxidant, anti-bacterial, anti-diabetic, wound healing, and abortifacient activities. Hibiscus rosa sinensis has been utilized in many herbal mix and drinks. This review plan to highlight the therapeutic application of Hibiscus rosa sinensis.

 

KEYWORDS: Hibiscus sinensis, Malvaceae, hypotensive.

 

 


INTRODUCTION:

Roselle Description Hibiscus has 300 species distributed around the world in tropical and subtropical regions and is used as ornamental plants. Studies have shown that certain Hibiscus species have some medicinal properties, of which roselle is one. Usually, Hibiscus sinensis is known as "red sorrel" or "roselle. “Even though permeable soil is that the best, Roselle can adapt to a spread of soil during a warmer and more humid climate.1 A part of the Malvaceae family, Hibiscus sinensis is a well-known medicinal plant with a worldwide reputation. In most warm countries, such as India, Saudi Arabia, Malaysia, Indonesia, Thailand, the Philippines, Vietnam, Sudan, Egypt and Mexico, the plant is also found.2,3 Roselle is especially cultivated to be consumed and therefore the main producers of Roselle blossoms are Egypt, Sudan, Mexico, Thailand and China. Other hibiscus varieties are planted for his or her fibers they produce. Hibiscus is belongs to the Malvaceae family, and its scientific name is China rose. it's an evergreen which is approximately 150-270cm tall. It’s strong branches and trunk; the leaves are dark green, shiny, smooth, and oval-shaped.3,4 This plant doesn't bear any fruit. Flowers are found in various shades e.g. red, white, yellow, and orange. Red hibiscus flowers are quite common and widely used for medicinal purposes. This drink is usually consumed iced, and is usually sweetened. it's a sour flavor and bears some resemblance to fruit juices. Although the dried tea seems like it's made up of petals, it's actually made up of the sepals (calyces), the tiny structures at the bottom of the flower. Many species of hibiscus are grown ornamentally, but the species roselle (also referred to as roselle) is that the commonest one utilized in herbal teas. China rose, or China rose, is additionally sometimes wont to produce herbal teas, but this text focuses on the sabdariffa species.5,6 The roselle species are often grown commercially, as a perennial, in hot tropical areas, or as an annual in colder climates. Hibiscus is additionally one among the foremost common ingredients in herbal blends; it even occurs because the main ingredient in many herbal blends widely available in supermarkets within the U.S. Hibiscus is quite acidic, and its commonest use in blends is to impart a sour taste and red or purple color, although it also imparts aroma also .In history, the medicinal plants are widely used for the varied purposes.7,8 The plants have identified as medicinal plants due to the power to synthesize chemical compounds which play major role to stop different diseases like cancer, diabetes, etc.  a strong verity of chemical compounds also have essential biological roles, and to protect against attack from predators including fungi, insects and herbivorous mammals. So far, at least 12,000 such compounds are isolated; variety estimated to be less than 10% of the total, medicinal plants are also considered and split into three significant sectors: (a) modern medicinal products using approximately 30 to 35 medicinal plants; (b) traditional medicinal products arranged and codified with written treatise texts, such as Ayurveda, Siddha, Unani, Amchi and Amchi. (c) local health traditions that are supported traditions practiced by villagers, folk healers, vaidyas, and tribal people that use quite 8,000 species of medicinal plants for primary health care purposes.9,10 The herb Hibiscus rosa sinensis L. (Malvaceae) is native to China. Many species of Hibiscus are grown for his or her showy flowers. it's a shrub widely cultivated within the tropics as a decorative plant and has several forms with varying colours of flowers. Hibiscus also has medicinal properties and is used in many herbal teas as a primary ingredient. In medicine, the red flowered variety is preferable. The taxonomy and therefore the name of Hibiscus flowers is shown in the Table in different regions. Different studies have shown that species of Hibiscus plants have different medicinal properties. This review focused primarily on the therapeutic potential of and applications of the Hibiscus rosa sinensis plant.11,12

 

 

Origin of roselle:

There is an enormous argument about the origin of Roselle among different scholars. Cobley suggested Roselle may be a native plant of West Africa and from there it had been carried to other parts of the planet like Asia and America, whereas in others opinion.13,14 Roselle was originated from India and Saudi Arabia. Varieties of Roselle Among numerous verities of Hibiscus, Hibiscus altissima and Hibiscus sabdariffa are the most typical and better introduced. Hibiscus altissima is branchless plant with yellow flowers and red or green colored calyxes. Though this species isn't used for food, this plant is more economically important than roselle because of its high fiber content. The opposite distinct type Hibiscus sabdariffa or “Roselle” grows during a bush with many branches.15,16

 

Taxonomy:17,18

Kingdom: Plantae-Plants

Subkingdom: Tracheobionta-Vascular plants.

Super division: Spermatophyta-Seed plants

Division: Magnoliophyta-Flowering plants

Class: Magnoliopsida-Dicotyledons

Subclass: Dilleniidae

Order: Malvales

Family: Malvaceae-Mallow family

Genus: Hibiscus L.-Rosemallow

Species: Hibiscus rosa sinensis L.-Shoeblackplant.

 

Synonyms:

Jamaica sorrel, Red sorrel, Roselle,

Indian sorrel Guinea sorrel.18,19

 

Phytochemistry:

Hibiscus rosa sinensis is well studied plant. The report suggested that it Tannins, Flavonoids, Steroids, alkaloids, Saponins, total phenols, Total flavonoids, total proanthocyanidin. It’s been also reported that it contains majorly anthocyanins and flavonoids; cyanidin-3,5-diglucoside, cyanidin-3-sophoroside-5-glucoside-3-sophoroside-5-glucoside, quercetin-3,7-diglucoside, quercetin-3-diglucoside.20,21 The opposite compounds also are present like cyclopeptide alkaloid. Cyanidin diglucoside, flavonoids and vitamins, thiamine, riboflavin, niacin and vitamin C are present in hibiscus flowers. The extract of Hibiscus rosa sinensis can be a source of several antioxidants and anticancer agents that are potentially active. Quercetin, glycosides, riboflavin, niacin, carotene, gentisic acid, heptadecanoic acid, and lauric acid are components. The Hibiscus roots. Sinensis includes sterols, glycosides and carbohydrates, tannin and phenolic compounds, triterpenes, saponins, mucilage and flavonoids.22,23

 

 

Pharmacology:

Anti helmentic and opposing microorganism effects:

Roselle is assumed for its medicinal drug, antifungal and anti-parasiticactions. Oil extracted from seeds of mallow has been shown to own an in vitro inhibitory result on associate Bacillus anthracis, Bacillus Bacilli and staphalbus. Chemical compound and plant material extracts were collectively found to be effective against genus mansoni and various microorganisms. Afolabiet al., incontestable the medicinal drug results of shrub extract on Streptococcus mutans, a bacterium from orifice. Very similar study, medicinal drug potential of shrub was collectively determined on Campylobacter species. Academic degree plant material extract of the dried leaves of Roselle reduce weapon of mass destruction formation and have in vitro inhibitory result against some fungi.24

 

Anti-oxidant effect:

Protecting property of a compound to inhibit the aerophilous mechanisms by scavenging reactive atomic number 8 and free radicals is thought as antioxidative activity. It protects lining organelles from premature cell harm and reduces ageing. An outsized range of in vitro and in vivo studies have shown that hibiscus calyxes contain potent inhibitor per theologian, each the entire binary compound and anthocyanin-rich extracts of hibiscus are effective inhibitor. Studies have conjointly highlighted that poly-phenolic acid, flavonoids and anthocyanins that are found in hibiscus are potentantioxidants.25

Blood pressure lowering effect:

The effectiveness of associate in nursing binary com hibiscus on delicate to moderate high bloewas as effective as captopril in treating delicate to moderate high blood pressure and there's no adverse impact with the treatment, confirming the effectiveness and safety of the extract. Even supposing the attainable mechanism (s) of action of hibiscus extract isn't investigated, daily consumption of associate in nursing aqueous hibiscus extract resulted in decrease in pulsation and pulsation blood pressure.26

 

Pimple:

If you're troubled regarding symptom drawback, then boil the mallow flowers in water and stir well. Add a bit honey thereto and apply it on your symptom this may cut back your symptom.

 

Cholesterol management:

Tea made of hibiscus leaves is extremely effective in reducing cholesterin and force per unit area. The weather found during this cut back the amount of steroid alcohol. For this, it's useful to drink water cooked with mallow flower. Excluding this, the tea made of mallow flower conjointly helps in up the system and metabolism perform. It’s conjointly smart for cancer and disease. This remedy is additionally effective in weight loss. You’ll be able to conjointly attempt Jiva Slim Tea that disclose blocked channels within the body, flushes toxins and helps in reducing weight.27

 

You can consume this handy Ayurvedic medicative plant – leaves and flowers to induce eliminate numerous health issues:

Itching and Burning:

Hibiscus flower conjointly advantages you from issues like itchiness and burning. Grind the leaves of mallow flower and apply it to scale back inflammation and burning sensation. when applying this paste, you'll get relief in an exceedingly couple of minutes.

 

Anti-inflammatory activity:

In male writer rats, H. genus Rosa sinensis hydroalcoholic leaves extract hadan ameliorating impact on four-dimensional ethanoic acid induced rubor via body part administration. The seven days treatment with two hundred mg/kg, p.o. of extract reduced the lesion space of colon to twenty. 67±2.40 mm2, as compared to10.00±1.23 mm2 from anti-inflammatory treatment cluster taken as positive control, and 41.67±1.96 mm2from negative management cluster. The phytochemicals that were gift like steroids, polyphenols, alkaloids, and flavonoids, might need contributed to the present activity. Ethanol extracts of flowers and leaves from 2 H. rosa-sinensismorpho types were conjointly tested on carrageenin induced paw puffiness in Sprague-Dawley rats. when six hours, the paw volume (ΔV, ml) was measured mistreatment phetlysmometer, and one hundred mg/kg dose was determined to have most remedial effect.

 

Anti-bacterial activity:

Wood alcohol extracts ready from the leaves of the H. rosa-sinensisis were shown to possess antimicrobial activities against Pseudomonas aeruginosa, Escherichia coli, Enterobacteraerogenes, and Streptococcus pyogenes. victimization well diffusion technique Associate in Nursingd when an incubation period of twenty four hours at 37° C, the utmost ascertained zone of inhibition was thirteen ± 00 millimeter and it absolutely was against E. coli followed by twelve ± 00mm against each S. aureus and E. aerogenes at eighty µg/ml concentration of leaves methanolic extract. These microorganisms were obtained from infected skins, and also the chemical compounds responsible for the antibacterial drug activity is also thanks to flavonoids, tannins, terpenoids, saponins, or alkaloids known within the study. In another study conducted victimization disc diffusion technique, extracts of forty mg/ml showed most zone of inhibition against B (14.00 ± 1.05mm), E. coli (12.30 ± 0.95mm) and S. aureus (11.00 ± 1.20 mm), whereas the wood alcohol extract showed the following zones of inhibitions against B. subtilis (18.82 ± 0.18 mm), E. coli (17.30 ± 0.51mm), S. aureus (15.20 ± 0.90 mm) when forty eight hours of incubation at 34° C. The screened phytochemicals were viscus glyxosides, anthraquinones, and phlobatanins, together with those mentioned earlier. Intresingly, another analysis reported similar results because the binary compound extracts showed a most zone of inhibition against B. subtillis as fifteen. 00±2.81mm, and E. coli as 12.50±1.81mm, while dissolver extracts gave the very best zone of inhibition against B. subtillis as nineteen. 86±0.15 mm, and E. coli as 18.00 ± 1.53mm.28

 

Immune response activity:

The impact of binary compound extracts of flowers on immunomodulation was studied by intraperitoneally injecting five hundred mg kg-1 warfare of extract in male Swiss unusual person mice. once fifteen days of treatment, protein humour levels accrued by fourteen.27% and IL-2 levels belittled by thirty two. 70% in comparison to regulate cluster. The protein titer conjointly accrued to a pair of.39ng ml-1 compared to one.73 ng ml-1in control cluster. Moreover, the extract accrued the scavenger cell yield and viability, additionally because the phagocytic index to seventy six.76 ± 1.40, that is barely seventy two.85 ± 1.07 up to speed group. HPTLC recording tried that it contains organic compound and flavonoids Using forced swim take a look at and unusual person Wistar rats as study models, ethylacetate extract of H. Rosa sinensis petals was evaluated at a hundred mg/kg dosage. The treatment accrued mean swim time by 2 fold, indicating higher tolerance to worry, and nearly restored back the normal levels of enzymes like amino acid aminotranferase (73.81±1.88IU/L), and aspartate transaminase (101.6±1.93 IU/L), compared to control values sixty six.79 ±1.44 and 93.61±4.49 IU/L, severally. Other physical stress indicators, like aldohexose, sterol, and triglycerides, were conjointly restored to their traditional values compared to control teams.29

 

Other uses:

Strengthens the Roots of Hair:

Hibiscus flowers and square leaves are rich in flavonoids and amino acids, which are energising ingredients. Flavonoids improve the circulation of blood to your hair follicles, turn inactive follicles into hair follicles, and promote new hair growth. In the cells of your hair follicles, amino acids induce scleroprotein production, promoting healthy hair growth. Premature greying of the hair can result from elevated tyranniddosha. Hibiscus is made from natural pigments, antioxidants and vitamins that will give your grey hair a crimson tinge and give your natural hair colour a darker shine.

 

The best way to grow long hair is to add mallow, mixed with copra oil. By minimising macromolecule loss, copra oil pacifies Vata Dosha, promotes hair growth and moisturises your hair.

 

Additional uses:

promotes hair growth, antitoxic, antibacterial, antifungal, anticancer, anti-fertility, neuroprotective activity, wound healing, antiinflammatory, antipyritic, antihyperlipidemic, carfioprotective, hepatopr-otective.30

 

CONCLUSION:

Hibiscus sabdariffa or "Roselle" is a medicinal plant containing a medicinal plant. Fame in the world Roselle, having several medically relevant compounds known as photochemical are recorded for their dietary purposes. The plant's seeds, leaves, fruit and roots they are used as herbal medicine and food. Roselle plays a vital role in the management of various medical conditions, including several Cardiovascular and cancer disorders, but more study is required. Understanding the precise mechanism of action and formulating food items Using Roselle with food products grown locally. Obesity can be an increasing concern, affecting not only adults, but also children. As previous clinical trials have shown promising effects on hyperlipidemia and hypertension, conditions closely associated with type II diabetes or metabolic syndrome, the efficacy of Roselle extract for metabolic disorders such as type II diabetes should be further investigated. The antioxidant compound interest in sight is the properties of the Hibiscus rosa sinensis plants Oxidative change. The problems associated with diabetes, such as hyperglycaemia, hypercholesteromia, and even regulated hyperlipidemia animals with Hibiscus rosa sinensis trees.

 

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Received on 05.02.2021       Modified on 27.02.2021

Accepted on 15.03.2021      ©A and V Publications All right reserved

Research Journal of Science and Technology. 2021; 13(2):151-156.

DOI: 10.52711/2349-2988.2021.00023