INTRODUCTION:

Pietro Biginelli synthesis 3,4-dihydropyrimidin-2(l/-&ones first time in 1893 by a simple one-pot condensation reaction of an aromatic aldehyde, urea and ethyl acetoacetate in ethanolic solution. This efficient approach to partly reduced pyrimidines, termed the Biginelli reaction or condensation was largely ignored n the following years, and therefore, also the synthetic potential of these multi-functionalized dihydropyrimidines (henceforth denoted as Biginelli compounds) remained unexplored¹. In recent years, however, interest in these compounds has significantly increased, and the scope of the original cyclocondensation reaction has been widely extended by variation of all three components.

Schematic representation of Biginelli reaction

Pyrimidine derivatives comprise a diverse and interesting group of drugs such as alkaloids, antibiotics, various agrochemicals, antimicrobial agents² and are extremely important for their biological activities Tetrahydropyrimidines (THPMs), also known as Biginelli compounds, have important therapeutic and pharmacological properties, as calcium-channel blockers, antihypertensive agents, HIV gp-120-CD4 inhibitors, and showing antitumor, antibacterial and anti-inflammatory activities³.

In this review compiles various reported derivatives of 1,2,3,4-Tetrahydropyrimidine-2-one. Several synthetic strategies have been reported for the preparation of the different derivatives of 1,2,3,4-Tetrahydropyrimidine-2-one, these derivatives are characterized by various techniques such as infrared spectroscopy, liquid chromatography-mass spectrometry, ¹H NMR and ¹³C NMR spectrometry along with single crystal X-ray diffraction. Recently Ultrasound and Microwave assisted synthesis of these derivates has been reported for better efficacy.

Tetrahydropyrimidine-2-one derivatives reported as,

Anatoly et al. carried out one-pot synthesis of 5-acyl-1,2,3,4-tetrahydropyrimidine-2-ones by reaction of the ureas with the sodium enolate of in acetonitrile followed by acidification and refluxing of the reaction mixtures. Further this was characterized by IR spectra, ¹H NMR, UV and TLC methods⁴.

Hamid et al. reported various Tetrahydropyrimidines derivatives such as 2-(Tetrahydropyrimidin-2(1H)-ylidene)-2-(1,4,5,6-tetrahydropyrimidin-2-yl) acetonitrile and 2-Cyano-2-(5,5-dimethyltetrahydropyrimidin-2(1H)-ylidene) ethanethioamide and (Z,E)-2-Cyano-2-(4-methylimidazolidin-2-ylidene) ethanethioamide, synthesized from the reaction of a single thioamide with several various diaminoalkanes and structure confirmed by ¹H-NMR, ¹³C-NMR, elemental analysis, and FT-IR spectrometry⁵.

Donna et al. synthesized 2- Hydroxy- and 2-mercapto-1,4,5,6-tetrahydropyrimidine by the condensation of urea and thiourea respectively with 1,3-Propanediamine with yield of about 30 – 50 %. 2-Phenyl-1,4,5,6-tetrahydropyrimidine hydrochloride was prepared in significant yield by the addition of hydrogen chloride gas to the free base in either benzene or absolute ethanol⁶.

Sangram et al. have reported various derivatives of 1,2,3,4-tetrahydropyrimidine with their spectral information. Some of derivatives are Ethyl 1,3,6-trimethyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; Ethyl 4-(4-methoxyphenyl)-1,3,6-trimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; Ethyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate and various other derivatives⁷.

Ctirad et al. in 1974 patented novel biologically active 1,2,3,6 tetrahydropyrimidine-2-one compounds, such compounds are 1-(2'-hydroxyphenyl)-4-(3'-nitrophenyl)-1,2,3,6-tetrahydropyrimidine-2-one which shows CNS depressant effects and 1-adamantyl-4-(3'-nitrophenyl)-1,2,3,6-tetrahydropyrimidine-2-one which shows CNS stimulant effects. The 1,2,3,6-tetrahydropyrimidine 2-one compounds having central nervous system activity are prepared by the reaction of a β-aminoketone and an alkali metal cyanate which results in a tetrahydropyrimidine-2-one compound bearing a double bond in the 4,5 position⁸.

Radhika et al. reported synthesis of 2-oxo-6-methyl-5-carbethoxy-4-aryl-1,2,3,4 tetrahydropyrimidine-2-one using Aldehyde, Ethyl acetoacetate, Urea, Iodine, sodium thiosulphate and ethanol (step1). Synthesized 4-aryl-5(hydrazinocarbomoyl)-6-methyl-1,2,3,4-tetrahydropyrimidine-2-one from product of step 1 using ethanol and Hydrazine hydrate (step 2). Further 5-mehyl-3-oxo-N₂[5’-carbonyl-(4’-aryl-6’methyl)-1’,2’,3’,4’-tetrahydropyrimidine-2’one] pyrazolidine is synthesized from product of step 2 using aryl hydrazine, ethyl acetoacetate, P-toluene sulfonic acid and ethanol, These compounds tested for anti-inflammatory using Diclofenac sodium and shown considerable anti-inflammatory activity. 5-methyl-3-oxo-N₂[5’-carbonyl-(4-(4-methoxy phenyl)-6’-methyl)-1’,2’,3’,4’-tetrahydro pyrimidine-2’-one] pyrazolidine has showm promising anti-inflammatory activity than standard drug Diclofenac sodium⁹.

Nima et al. synthesized series of new 1,2,3,4-tetrahydropyrimidine derivatives within a one-pot three component Biginelli reaction. The structures of compounds were characterized by FT-IR, ¹HNMR, mass spectroscopy and elemental analysis. Benzyl 4-(3-bromophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; Benzyl 4-(4-fluorophenyl)–6- methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; and Benzyl 6-methyl-2-oxo-4- phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate showed the highest antibacterial and cytotoxic activities¹⁰.

Manish et al. synthesized various Ethyl-6-methyl-2-oxo-4-substituted phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate and 6-methyl-2-oxo-4-substituted phenyl-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide and 6– Methyl –4–aryl–5-(5-phenyl-1,3,4–oxadiazol-2-yl)-1,2,3,4-tetrahydropyrimidine-2(1H)-one. Further tested for antimicrobial activity and shown promising activity¹¹.

Vishwakarma et al. reported various derivatives of 5-isonicotinoyl-1,2,3,4-tetrahydropyrimidines by reaction of primary amines and formaldehyde. This synthesized derivative is further reacted with diamines and formaldehyde to give hitherto unreported bis-tetrahydropyrimidines. From this (1,2,3,4-Tetrahydro-3-benzyl-1-phenylpyrimidin-5-yl)(pyridin-4-yl)methanone and (1,2,3,4-Tetrahydro-1,3-dibenzylpyrimidin-5-yl)(pyridin-4-yl)methanone and (1,2,3,4-Tetrahydro-1-benzyl-3-methylpyrimidin-5-yl)(pyridin-4-yl)methanone and (1,2,3,4-Tetrahydro-1-methyl-3-phenylpyrimidin-5-yl)(pyridin-4-yl)methanone and (1,2,3,4-Tetrahydro-3-benzyl-1-methlpyrimidin-5-yl)(pyridin-4-yl)methanone derivatives possess anti-bacterial activity on gram-positive bacteria¹².

Katharigatta et al. synthesized substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives were synthesized by reacting dihydropyrimidinones, having a terminal alkynyl group, and different substituted aryl azides with use of a catalytic amount of Cu(OAc)₂ and sodium ascorbate in (1:2) of acetone and water as a solvent, performed at room temperature. The newly synthesized compounds were characterized by a number of spectroscopic techniques, such as infrared, liquid chromatography-mass spectrometry, ¹H, and ¹³C nuclear magnetic resonance along with single crystal X-ray diffraction¹³.

Akbari et al. synthesized tetrahydropyrimidines derivatives which are N-(4-chlorophenyl)-6-methyl-4-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide and N-(4-chlorophenyl)-7-methyl-5-aryl-2,3-dihydro-5H-thiazolol[3,2-a]pyrimidine-6-carboxamide by the reaction of N-(4-chlorophenyl)-3-oxobutanamide, thiourea and different aromatic aldehydes & cyclocondensation of 1,2,3,4-tetrahydropyrimidine-2-thiones 4(a–h) and 1,2-dibromoethane respectively, further these were evaluated for antimicrobial activities, in this some derivatives shows significant inhibition on bacterial and fungal growth and the structures are confirmed by IR, ¹H-NMR, and Mass spectral studies¹⁴.

Mokale et al. reported synthesis of tetrahydropyrimidines derivatives which are 5-(4-subtituted phenyl)-5-oxopentanoic acid and 3-(4,6-disubtituted-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)propanoic acid have been synthesized by condensation of thiourea, 5-(4-subtituted phenyl)-5-oxopentanoic acid and substituted aldehyde and their anti-inflammatory activity is checked by rat paw edema method. The compounds were confirmed by ¹H NMR and Mass spectral analysis¹⁵.

Ashoka et al. synthesized ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivative is by reaction of substituted aldehydes, ethylacetoacetate and ammonium acetate using ethanol as a solvent with cyclic voltametric studies on SnO₂ nanoparticle modified carbon paste electrode (MCPE). The synthesized compound were screened for their antimicrobial activity against Gram-negative bacterias and fungi and showed promising antimicrobial activity¹⁶.

Kshirsagar et al. have synthesized Ethyl-6-methyl-2-oxo-4-substitutedphenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 6–Methyl–2–oxo–4–substitutedphenyl-1,2,3,4–tetrahydropyrimidine-5-carbohydrazide and 6– Methyl-2-oxo–4–substituted–5-(5-phenyl-1,3,4–oxadiazol-2-yl)-1,2,3,4-tetrahydropyrimidine-2(1H)-one obtained by synthesis of DHPM using substituted aldehydes and conversion of DHPM to the respective hydrazides followed by treatment with phosphorus oxychloride and dichloroethane and confirmed by spectroscopic and elemental analysis¹⁷.

Ramesh et al. synthesized a series of 2-methylthio-1,4-dihydropyrimidine derivatives by alkylation of 1,2,3,4-tetrahydropyrimidines with methyl iodide in the presence of pyridine. This are confirmed by elemental analysis, IR and ¹H NMR spectra¹⁸.

Olayinka et al. reported synthesis of tetrahydropyrimidines derivatives which are ethyl 4-(4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 4-(4-hydrophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide and of N’-(alkanylidene)-4-(4-hydrophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide. Structures confirmed by spectroscopic means including IR, UV, ¹H-NMR, ¹³C-NMR and DEPT-135 as well as analytical data. Synthesized compounds are proposed for further study of anti-plasmodium activity¹⁹.

Ramesh et al. synthesized a series of 2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides and 3-oxo-2,3,8,8a-tetrahydro-5H-[1,3] thiazolo [3,2-a]pyrimidine-6-carboxamides derivatives synthesized by using microwave. Structures of compounds were confirmed by elemental analysis, IR, ¹H NMR and mass spectral data and have shown potent antipsychotic activity²⁰.

Hamid et al. reported synthesis of tetrahydropyrimidines derivatives which are 2-(4,5-Dihydro-1H-imidazol-2-yl)-2-(imidazolidin-2-ylidene) acetonitrile and 2-Cyano-2-(5,5-dimethyltetrahydropyrimidin-2(1H)-ylidene) ethanethioamide from the reaction of a single thioamide with several various diaminoalkanes. Compounds were confirmed by ¹H NMR, ¹³C NMR, elemental analysis, and FT-IR spectrometry²¹.

Haitham et al. have synthesized various derivatives such as ethyl-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro pyrimidine-5-carboxylate; 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide from underwent condensation with various aromatic aldehydes. All compounds were characterized by various spectroscopic techniques. They possess prominent antimicrobial and antifungal activity²².

Hery et al. reported synthesis of ethyl 4-[5-(methoxymethyl) furan-2-yl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate by one-pot multicomponent Biginelli reaction and was characterized by spectroscopic evidence, FTIR, HRESI-MS, 1D-, and 2D NMR²³.

Marwa et al. reported synthesis of various tetrahydropyrimidine using 6-(benzo[d][1,3] dioxol-5-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahy-dropyrimidine-5-carbonitrile; 2-(6-(Benzo[d][1,3]dioxol-5-yl)-5-cyano-2-thioxo-1,2-dihydropyrimidin-4-ylamino)acetic Acid and 4-(Benzo[d][1,3]dioxol-5-yl)-2-(ethylthio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile. Synthesized compounds were characterized by IR, ¹H-NMR, ¹³C-NMR, and mass spectral data. Antioxidant activities of all synthesized compounds were investigated²⁴.

Atul et al. synthesized a series of 1,2,3,4-tetrahydro-N-(substitutedphenyl)-6-methyl-2-oxo-4-(4-(phenoxymethyl) phenyl) pyrimidine-5-carboxamide derivatives. The products were confirmed by FT-IR, ¹H NMR, Mass spectra and elemental analysis. The newly synthesized compounds were subjected to antimicrobial activities²⁵.

Ambareen et al. synthesized a series of ethyl 6-methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidine-5-carboxylate and 6-methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide and N’-((2-chloroquinolin-3-yl)methylene)-4-(aryl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide and 5-(4-acetyl-5-(2-chloroquinolin-3-yl)-4,5-dihydro-1,3,4-oxadiazol-2-yl)-6-methyl-4-(aryl)-3,4-dihydropyrimidin-2(1H)-one derivatives incorporating substituted dihydropyrimidinone and chloroquinoline moieties. Structural characterization is done by FTIR, ¹H NMR and Mass spectroscopy²⁶.

Mariana et al. synthesized a series of potential antitumoral agents as 3,4-dihydropyrimidin-2-(1H)-one and Tetrahydropyrimidine derivatives by using the reagents urea, benzaldehyde, p-tolualdehyde, p-nitrobenzaldehyde, 2,4-dichlorobenzaldehyde and 2,3-difluorobenzaldehyde²⁷.

Narkhede et al. synthesized a series of 2-[1-(6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) ethylidene] hydrazine carbothioamide and 2-[1-(6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) ethylidene] hydrazine carboxamide and 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carbohydra- zide by using Biginelli condensation reaction and derivatives synthesized from substituted aryl aldehydes, thiourea or urea and1, 3-dicarbonyl compounds. The compounds were analyzed by FTIR using KBr pellet²⁸.

Kastron et al. reported synthesis of derivatives of 2-oxo-l,2,3,4-tetrahydropyrimidine-5-carboxylic acid by a modified Biginelli condensation, starting with urea or its derivatives, acetoacetic acid esters or acetylacetone, and o-difluoromethoxybenzaldehyde. The structure was confirmed by IR and PMR spectra²⁹.

Naglaa et al. reported synthesis of derivatives of 6-(4-methoxyphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrileas a key starting material to design-and synthesize a library of biologically active series of polyfunctionalized pyrimidine-2-thionederivatives. Structural characterization confirmed by elemental analysis, IR and ¹H NMR spectra³⁰.

Brimblecombe et al. reported synthesis Tetrahydropyrimidines derivatives of l-p-nitrophenylethyl-2-benzyl-1,4,5,6-tetrahydropyrimidine by aralkylation of 2-benzyl-1,4,5,6-tetrahydropyrimidine with p-nitro-phenethyl bromide. The results of other tests confirm that the main pharmacological action of the compounds is of the" nicotinic action³¹.

Naser et al. reported a series of 5-Ethoxycarbonyl-4,6-diphenyl-1,2,3,4-tetrahydropyrimidine-2-thione derivatives via Biginelli reaction using HCl or DABCO as a catalyst with good yields. All structures of products were confirmed by IR, ¹H NMR and ¹³C NMR spectroscopy³².

Monteiro et al. reported a series of 2-(-5-amino-1-aryl-1H-pyrazol-4-yl)-1,4,5,6-tetrahydropyrimidines from and 1,3-diaminopropane, respectively, using carbon disulfide (CS₂) as catalyst derivatives, structures of products were confirmed by IR, mass, ¹H NMR and ¹³C NMR spectroscopy. The products were evaluated for cytotoxicity in Vero cells³³.

Jimish et al. reported synthesis of QSAR model development of 51 tetra-hydropyrimidine-2-one was carried out to predict HIV-1 protease receptors inhibitors activity. When dataset was subjected to sequential multiple linear regression analysis, several equations were obtained. Out of these, three most statistically significant equations were considered as the best models³⁴.

Khanina et al. reported synthesis of derivatives of 2-Thioxo-4-phenyl-5-methoxycarbonyl-6-methyl-l,2,3,4-tetrahydropyrimidine. The course of the reaction was monitored by TLC on Silufoi UV-254 plates in a chloroform-hexane-acetone system (9:7:1).

And the compounds were confirmed by 1H NMR³⁵.

Fan-Jie et al. reported a series of Ethyl 4,6-Bis(4-chlorophenyl)-2-hydroxypyrimidine-5-carboxy-late by the products of the well-known Biginelli three-component condensation reaction. All structures of products were confirmed by 1H NMR, ¹³C{1H} NMR, and ¹⁹F NMR spectra³⁶.

Shubhangi et al. reported synthesis of Ethyl-6-methyl-2-oxo/thioxo-4-substituted phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates and 6-methyl-2-oxo/thioxo-4-substituted phenyl-1,2,3,4-tetrahydropyrimidine-5-carbo hydrazide and 6-methyl-4-aryl-5-(5-phenyl-1,3,4-oxadiazole-2-yl)-1,2,3,4-tetrahydropyrimidine-2-(1H)-one/ thione derivatives were carried out by Hanztsch method followed by hydrazine hydrate in ethanol obtained carbohydrazides subjected to Microwave irradiation for 2-4 minutes, followed by cyclisation in POCl₃ gave oxadiazoles. The newly synthesized compounds were established on the basis of IR, ¹H-NMR and Mass spectroscopic method³⁷.

Aniket et al. reported a series of Maleic acid catalyzed 3,4-Dihydropyrimidin-2-(1H)-ones and their thione analogues have been synthesized by condensation of aromatic aldehydes, β-dicarbonyl compound and urea or thiourea in the presence of alcohol-water (2:1; v/v) under mild reaction conditions. All synthesized derivatives were characterized using mass and ¹H NMR³⁸.

Sara et al. studied a series of thirty-nine novel 1,2,3,4-tetrahydropyrimidinone (thione)s were subjected to conformational studies. Results of this work confirm a twisted boat tetrahydropyrimidine ring conformation with an axial C₄ substituent for most of the compounds³⁹.

Parthiv et al. reported synthesis of 4-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-N-(4-methoxyphenyl)-6-methyl-2-oxopyrimidine-5-carboxamide and 4-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-N-(4-methoxyphenyl)-6-methyl-2-thiopyrimidine-5-carboxamide. The derivatives are synthesized via a multicomponent reaction of aldehyde derivative, urea or thiourea and 1,3-dicarbonyl compounds using Biginelli Reaction. All the product were characterized by melting point, ¹H NMR, IR, mass spectra and CHN analysis⁴⁰.

Sandip et al. reported a series of Ethyl-6-methyl-2-oxo-4-substituted-1,2,3,4-tetrahydropyrimidine-5-carboxylate-1-carbamides by carbohydrazine on treating hydrazine hydrate and then to azide, which was converted to carbamate and carbamide on treating with ethanol/ phenols/ amines. All compounds were characterized by elemental analysis, IR, ¹H NMR spectra & Mass spectroscopy⁴¹.

Niharika et al. reported synthesis of [4Substituted Phenyl 5Ethoxy Carbonyl6Methyl]3,4Dihydropyrimidine 2 (1H)one and Ethyl(2–Ethoxy–2Oxoethyl)–6–Methyl–2–oxo–4–Phenyl–1,2,3,4Tetrahydropyrimidine–5Carboxylate and Ethyl 1(2Hydrazino2Oxoethyl)6Methyl2oxo4Phenyl1,2,3,4tetrahydropyrimidine 5Carboxylate is by reaction of aldehyde, ethyl acetoacetate and urea along with refluxing with ethanol, hydrazine hydrate (for 24 hours) following Biginelli reaction and microwave irradiation technique which is found efficient and time saving. All compounds confirmed by analytical and spectral data. Compounds showed significant antibacterial activity⁴².

Behzad et al. studied synthesis of a series Tetrahydropyrimidines such as 2-(5,5-Dimethyltetrahydropyrimidin-2(1H)-ylidene) malononitrile; 2-(4-Ethyltetrahydropyrimidin-2(1H)-ylidene) malononitrile; 2-(4,4-Dimethylimidazolidin-2-ylidene) malononitrile. All structures was confirmed by single crystal X-ray diffraction and elemental analysis, proton nuclear magnetic resonance (¹H-NMR), carbon-13 nuclear magnetic resonance (¹³C-NMR) and infrared (IR) spectroscopy. The synthesized derivatives were evaluated for antibacterial effect⁴³.

Balaswamy et al. reported synthesis of series of polysubstituted 1,2,3,6-tetra-hydro-pyrimidine derivatives by pyrimidines under TBAB mediated one-pot, multi-component domino cyclization reaction. All compounds were characterized by elemental analysis, IR, NMR spectra & Mass spectroscopy⁴⁴.

Marwaet et al. reported a series of 6-(Benzo[d][1,3]dioxol-5-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile has been utilized for synthesis synthesized from the reaction of tetrahydropyrimidine with different reagents. The newly synthesized compounds were characterized by IR, ¹H-NMR, ¹³C-NMR, and mass spectral data. Antioxidant activities of all synthesized compounds were investigated⁴⁵.

Saurabh et al. reported synthesis of 6-methyl-4-substituted-phenyl-2-oxo(thioxo)-l,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl esters by solvent-less dry media (bentonite clay)supported- copper perchlorate as catalyst under ultrasonic irradiation. The structure of the products formed has been confirmed by elemental analyses, NMR, IR⁴⁶.

DISCUSSION:

Information provide in this review is an attempt to compile various derivatives of Tetrahydropyrimidine-2-one at single platform. The information derived from the present review may be useful in the design of more potent substituted tetrahydropyrimidine-2-one derivatives.

ACKNOWLEDGEMENT:

The authors are grateful to the authorities of Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413 736, Dist- Ahmednagar for providing facilities for literature review.

CONFLICT OF INTEREST:

The authors declare no conflict of interest.

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Received on 10.03.2021 Modified on 15.04.2021

Research J. Science and Tech. 2021; 13(3):221-228.

DOI: 10.52711/2349-2988.2021.00035