Author(s): Bhupendra M. Mahale, Akshata M. Girase, Maheshwari M. Mahale

Email(s): bhupendramahale999@gmail.com

DOI: 10.52711/2349-2988.2024.00047   

Address: Bhupendra M. Mahale1*, Akshata M. Girase2, Maheshwari M. Mahale3
1Pharmaceutics, Kavayitri Bahinabai Chaudhari NMU University, P.S.G.V.P. Mandal’s College of Pharmacy, Shahada, Maharashtra, India.
2Pharmaceutical Quality Assurance, Kavayitri Bahinabai Chaudhari NMU University, P.S.G.V.P. Mandal’s College of Pharmacy, Shahada, Maharashtra, India.
3Pharmaceutics, Dr. Babasaheb Ambedkar Technological University, Ahinsa Institute of Pharmacy, Dondaicha, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 4,     Year - 2024


ABSTRACT:
The synthetic oestrogen receptor-related orphan receptor (ERR) agonist SLU-PP-332 exhibits promising potential in revolutionizing fitness and weight loss strategies. Through its activation of ERRs, SLU-PP-332 enhances energy expenditure, increases fatty acid oxidation, and reduces fat mass buildup. Studies indicate its ability to mimic exercise-induced metabolic pathways, resulting in improved endurance and weight loss in mice. While long-term implications are yet to be fully understood, initial trials show no significant adverse effects. SLU-PP-332 targets ERRs found in various human organs, influencing vital metabolic processes. With implications for treating metabolic disorders like obesity, type 2 diabetes, and heart failure, SLU-PP-332 emerges as a novel therapeutic agent. Its biological activity, structure, and solubility data support its potential as a small molecule drug in endocrinology and metabolic diseases. Further research is warranted to elucidate its long-term effects and refine its structure for future clinical applications


Cite this article:
Bhupendra M. Mahale, Akshata M. Girase, Maheshwari M. Mahale. Unlocking the potential: SLU-PP-332 and the future of exercise Enhancement and Metabolic health. Research Journal of Science and Technology. 2024; 16(4):321-4. doi: 10.52711/2349-2988.2024.00047

Cite(Electronic):
Bhupendra M. Mahale, Akshata M. Girase, Maheshwari M. Mahale. Unlocking the potential: SLU-PP-332 and the future of exercise Enhancement and Metabolic health. Research Journal of Science and Technology. 2024; 16(4):321-4. doi: 10.52711/2349-2988.2024.00047   Available on: https://rjstonline.com/AbstractView.aspx?PID=2024-16-4-9


REFERENCE:
1.    Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, et al. A Synthetic ERR Agonist Alleviates Metabolic Syndrome. J Pharmacol Exp Ther. 2023: JPET-AR-2023-001733. doi: 10.1124/ jpet.123.001733.
2.    Egan, B.; Zierath, J. R. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013; 17: 162− 184.
3.    Ludvik B. Gewichtsreduktion durch Steigerung des Energieverbrauchs und der Thermogenese [Weight loss by increasing energy consumption and thermogenesis]. Acta Med Austriaca. 1998; 25: 136-7
4.    Lee J, Joh Y, Choi C, Kim K, Lee YH. A Combination of Soy Isoflavone and L-Carnitine Improves Running Endurance in Mice. Nutrients. 2023; 15: 3678. doi: 10.3390/nu15173678
5.    Schoepke EL. Pharmacological Modulation of the Estrogen Related Receptors Alters Cellular Metabolism [dissertation]. Saint Louis University; 2021.
6.    https://www.medchemexpress.com/slu-pp-332.html
7.    https://synapse.patsnap.com/drug/d49bda4b65c346de83f57ea1a317688d#overview
8.    https://www.medkoo.com/products/53978
9.    https://en.wikipedia.org/wiki/SLU-PP-332#/media/File:SLU-PP-332_structure.png
10.    Sharma A, Madaan V, Petty FD. Exercise for mental health. Prim Care Companion J Clin Psychiatry. 2006; 8: 106. doi: 10.4088/pcc.v08n0208a.
11.    Committee on Physical Activity and Physical Education in the School Environment; Food and Nutrition Board; Institute of Medicine; Kohl HW III, Cook HD, editors. Educating the Student Body: Taking Physical Activity and Physical Education to School. Washington (DC): National Academies Press (US); 2013 Oct 30. 3, Physical Activity and Physical Education: Relationship to Growth, Development, and Health. Available from: https://www.ncbi.nlm.nih.gov/books/NBK201497/.
12.    Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, et al. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023; 18: 756-771. doi: 10.1021/ acschembio.2c00720
13.    Kim WY, Sharpless NE. Drug efficacy testing in mice. Curr Top Microbiol Immunol. 2012; 355: 19-38. doi: 10.1007/82_2011_160.
14.    Hanson AM, Perera KLIS, Kim J, Pandey RK, Sweeney N, Lu X, et al. A-C Estrogens as Potent and Selective Estrogen ReceptorBeta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions. J Med Chem. 2018; 61: 4720- 4738. doi: 10.1021/acs.jmedchem.7b01601.
15.    Liu X, Zhang Z, Song Y, Xie H, Dong M. An update on brown adipose tissue and obesity intervention: Function, regulation, and therapeutic implications. Front Endocrinol (Lausanne). 2023; 13: 1065263. doi: 10.3389/fendo.2022.1065263.
16.    Smith RL, Soeters MR, Wüst RCI, Houtkooper RH. Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease. Endocr Rev. 2018; 39: 489-517. doi: 10.1210/er.2017-00211
17.    Otto, G. P.; Rathkolb, B.; Oestereicher, M. A.; Lengger, C. J.; Moerth, C.; Micklich, K.; Fuchs, H.; Gailus-Durner, V.; Wolf, E.; Hrabe de Angelis, M. Clinical Chemistry Reference Intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ Mice (Mus musculus). J. Am. Assoc. Lab. Anim. Sci. 2016; 55: 375−386.
18.    Villena, J. A.; Hock, M. B.; Chang, W. Y.; Barcas, J. E.; Giguere, V.; Kralli, A. Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis. Proc. Natl. Acad. Sci. U.S.A. 2007; 104: 1418−1423
19.    https://www.tocris.com/products/slu-pp-332_8112

Recomonded Articles:

Author(s): Mohini Shelke, Shraddha Parjane, S. D Mankar, S. S. Siddheshwar

DOI: 10.52711/2349-2988.2021.00023         Access: Open Access Read More

Author(s): K. Parameswari , T. Ananthi

DOI:         Access: Open Access Read More

Author(s): Bhushan S. Mahajan, Bhupendra Sing P. Mahale, Amol R. Pawar, Vikas V. Patil, Pankaj S. Patil, Jayesh Songire

DOI: 10.52711/2349-2988.2024.00020         Access: Closed Access Read More

Author(s): Bhupendra M. Mahale, Akshata M. Girase, Maheshwari M. Mahale

DOI: 10.52711/2349-2988.2024.00047         Access: Closed Access Read More

Research Journal of Science and Technology (RJST) is an international, peer-reviewed journal, devoted to science and technology...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2349-2988 


Recent Articles




Tags