Pomegranate in Breast Cancer: A Comprehensive Review of its Therapeutic Potential

Kanchan Rajendra Pawar

doi:10.52711/2349-2988.2025.00005

Research Journal of Science and Technology

ISSN

2349-2988 (Online)
0975-4393 (Print)

Submit Article

Pomegranate in Breast Cancer: A Comprehensive Review of its Therapeutic Potential

Author(s): Kanchan Rajendra Pawar

Email(s): pawark200435@gmail.com

DOI: 10.52711/2349-2988.2025.00005

Address: Kanchan Rajendra Pawar
Shantiniketan College of Pharmacy, Dhotre, Maharashtra, India.
*Corresponding Author

Published In: Volume - 17, Issue - 1, Year - 2025

View HTML

Purchase PDF

ABSTRACT:
Punica granatum L., commonly known as the pomegranate, is a fruit-bearing plant native to Iran and belonging to the Punicaceae family. Characterized by its large, globular berries containing numerous seeds enveloped in a juicy, edible pulp, pomegranate has been employed for centuries in various cultures to prevent and treat a multitude of health disorders, including inflammation, diabetes, diarrhea, dysentery, and dental plaque. Aim of the Review: This review aims to provide an up-to-date, comprehensive overview of the chemical constituents, traditional uses, phytochemistry, pharmacology, and toxicology of Punica granatum L. Specifically, this review focuses on the potential exploitation of this species to treat diverse diseases and suggests future investigations. The increasing demand for complementary medicine has driven the search for effective alternative therapies that minimize adverse effects associated with conventional drugs. Pomegranate has garnered significant attention due to its remarkable nutritional and medicinal properties. In Mexico, the harvest and consumption of pomegranate have surged, driven by recent discoveries of phytochemical compounds exhibiting antioxidant, anti-inflammatory, and antiviral activities, with promising applications in the food industry.

Keywords:

Cite this article:
Kanchan Rajendra Pawar. Pomegranate in Breast Cancer: A Comprehensive Review of its Therapeutic Potential. Research Journal of Science and Technology. 2025; 17(1):35-0. doi: 10.52711/2349-2988.2025.00005

Cite(Electronic):
Kanchan Rajendra Pawar. Pomegranate in Breast Cancer: A Comprehensive Review of its Therapeutic Potential. Research Journal of Science and Technology. 2025; 17(1):35-0. doi: 10.52711/2349-2988.2025.00005 Available on: https://rjstonline.com/AbstractView.aspx?PID=2025-17-1-5

REFERENCE:
1.    Holland D, Bar-Ya’akov I. Pomegranate (Punica granatum L.) breeding. Advances in Plant Breeding Strategies: Fruits. 2018; 3: 601-47.
2.    Pellow BJ, Henwood MJ, Carolin RC. Flora of the Sydney region: a complete revision. Sydney University Press; 2009.
3.    Ganapathy M. Campus. Forestry. 36: 454-89.
4.    Mellado-Negrete A, Peña-Vázquez GI, Urías-Orona V, De La Garza AL. Polyphenol bioaccessibility and antioxidant activity of pomegranate (Punica granatum) peel supplementation in diet-induced obese rats. Journal of Medicinal Food. 2023 Aug 1; 26(8): 570-9.
5.    Sharma J, Maity A. Pomegranate phytochemicals: Nutraceutical and therapeutic values. Fruit Veg. Cereal Sci. Biotech. 2010; 4: 56-76.
6.    Mokapane FM. Effects of pre-treatments to preserve quality attributes and prolong shelf-life of dried pomegranate arils (Doctoral dissertation, Stellenbosch: Stellenbosch University).
7.    Alamgir AN, Alamgir AN. Vitamins, nutraceuticals, food additives, enzymes, anesthetic aids, and cosmetics. Therapeutic Use of Medicinal Plants and their Extracts: Volume 2: Phytochemistry and Bioactive Compounds. 2018:407-534.
8.    Rebelo JM. Impact of the use of an educational Web-Application on nutritional knowledge and food consumption in children and adolescents with overweight or obesity.
9.    Athmaselvi KA, Kumar C, Poojitha P. Interventions of Ohmic Heating Technology in Foods. State-of-the-Art Technologies in Food Science: Human Health, Emerging Issues and Specialty Topics. 2018 Aug 14:321.
10.    Rahman MM. Medicinal Plants Used as an Alternative to Treat Gingivitis and Periodontitis.
11.    Muni W. An Eight-hundred-Year-Old Book of Indian Medicine and Formulas. Asian Educational Services; 1992.
12.    Bokemeyer C, Foubert J. Anemia impact and management: focus on patient needs and the use of erythropoietic agents. In Seminars in Oncology 2004 Jun 1 (Vol. 31, pp. 4-11). WB Saunders.
13.    Della Sopravvivenza Nell’infarto S. Effects of reviparin, a low-molecular-weight heparin, on mortality, reinfarction, and strokes in patients with acute myocardial infarction presenting with ST-segment elevation. JAMA. 2005; 293: 427-36.
14.    Friedlander AH, Mahler ME. Major depressive disorder: psychopathology, medical management and dental implications. The Journal of the American Dental Association. 2001 May 1; 132(5): 629-38.
15.    Milner JA. Reducing the risk of cancer. In Functional foods: Designer foods, pharmafoods, nutraceuticals 1994 (pp. 39-70). Boston, MA: Springer US.
16.    Liu M, Chen S, Zhang Z, Li H, Sun G, Yin N, Wen J. Anti-ageing peptides and proteins for topical applications: A review. Pharmaceutical Development and Technology. 2022 Jan 2; 27(1): 108-25.
17.    Aher YL, Rahane S. A review of pomegranate cultivation. Int Res J Eng Tech. 2016; 3(4): 2083-8.
18.    Kandylis P, Kokkinomagoulos E. Food applications and potential health benefits of pomegranate and its derivatives. Foods. 2020 Jan 23; 9(2): 122.
19.    Valero-Mendoza AG, Meléndez-Rentería NP, Chávez-González ML, Flores-Gallegos AC, Wong-Paz JE, Govea-Salas M, Zugasti-Cruz A, Ascacio-Valdés JA. The whole pomegranate (Punica granatum. L), biological properties and important findings: A review. Food Chemistry Advances. 2023 Oct 1; 2: 100153.
20.    Bishayee A, Thoppil RJ, Darvesh AS, Ohanyan V, Meszaros JG, Bhatia D. Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis. The Journal of nutritional biochemistry. 2013 Jan 1; 24(1): 178-87.
21.    Pande SD, Wagh AS, Bhagure LB, Patil SG, Deshmukh AR. Preparation and evaluation of phytosomes of pomegrane peels. Research Journal of Pharmacy and Technology. 2015;8(4):416-22.
22.    Alabsi AM, Ali R, Ali AM, Al-Dubai SA, Harun H, Abu Kasim NH, Alsalahi A. Apoptosis induction, cell cycle arrest and in vitro anticancer activity of gonothalamin in a cancer cell lines. Asian Pacific Journal of Cancer Prevention. 2012; 13(10): 5131-6.
23.    Riaz S, Rasul A, Ahmad M, Asrar M, Hassan M. Pomegranate Peel Extract as 6-Phosphogluconate Dehydrogenase (6PGD) Inhibitor for Treatment of Breast Cancer. Cell Biochemistry and Biophysics. 2024 Sep 5: 1-7.
24.    Krishna Bayineni V, Naira VR, Kadeppagari RK. Biomedical Applications of Nanozymes: Disease Diagnosis and Therapy. InHandbook of Consumer Nanoproducts 2022 May 6 (pp. 675-687). Singapore: Springer Nature Singapore.
25.    Syed D, Malik A, Hadi N, Schmitt C, Afaq F, Mukhtar H. Molecular mechanisms of chemoprevention of cancer by pomegranate. In Pomegranates. 2006 Jul 7 (pp. 135-150). CRC Press.
26.    Liu ZL, Chen HH, Zheng LL, Sun LP, Shi L. Angiogenic signaling pathways and anti-angiogenic therapy for cancer. Signal Transduction and Targeted Therapy. 2023 May 11; 8(1): 198.
27.    Lokeshwar BL. MMP inhibition in prostate cancer. Annals of the New York Academy of Sciences. 1999 Jun; 878(1): 271-89.
28.    Banerjee N. Polyphenol-induced Anti-inflammatory and Cytotoxic Activities in Breast and Colon Cancer: Potential Role of miRNA's in Cell Survival and Inflammation (Doctoral dissertation).
29.    Yang X, Niu Z, Wang X, Lu X, Sun J, Carpena M, Prieto MA, Simal-Gandara J, Xiao J, Liu C, Li N. The nutritional and bioactive components, potential health function and comprehensive utilization of pomegranate: a review. Food Reviews International. 2023 Oct 3; 39(9): 6420-46.
30.    Zeng X, Liu C, Yao J, Wan H, Wan G, Li Y, Chen N. Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications. Pharmacological Research. 2021 Jan 1; 163: 105320.
31.    Jeune ML, Kumi-Diaka J, Brown J. Anticancer activities of pomegranate extracts and genistein in human breast cancer cells. Journal of medicinal food. 2005 Dec 1; 8(4): 469-75.