ABSTRACT:
Dengue is a viral disease that is endemic in more than 100 countries especially in the South East Asia and Western Pacific regions. The rapid growth in population and sudden climatic changes has contributed to the increase. The World Health Organization has classified dengue into three types: dengue fever, dengue hemorrhagic fever and dengue shock syndrome. Annually, around 50-100 million people living in subtropical countries are infected by dengue. Symptoms occur usually 3 to 14 days after spread by Aedes [Aedes aegypti] mosquitoes and consist of fever, headache, vomiting, pains and aches in muscle and joints and a typical rash. The symptoms last for 2 to 7 days. A novel vaccine for dengue fever has been approved in three countries, but is not yet commercially available. Dengue fever is caused by flavi virus which belongs toFlaviviridae family. flavi virus is a positive single stranded RNA virus which enter inside thecell by receptor-mediated endocytosis andfuse their membrane with that of the endosome. The virus genome then enters into cytoplasm and forms immature virions that enter into exocytotic pathway of cell and perform proteolysis.