A Review on Neem Nanoparticles used in Cancer Therapy

Vaishnavi Ashok Gore

doi:10.52711/2349-2988.2026.00038

Research Journal of Science and Technology

ISSN

2349-2988 (Online)
0975-4393 (Print)

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A Review on Neem Nanoparticles used in Cancer Therapy

Author(s): Vaishnavi Ashok Gore

Email(s): vaishnavigore04042004@gmail.com

DOI: 10.52711/2349-2988.2026.00038

Address: Vaishnavi Ashok Gore
Swastyadarpan Pratishthan’s, Shantiniketan College of Pharmacy, A/P Dhotre (B.K.), Tal. Parner, Ahmednagar, Maharashtra – 414302.
*Corresponding Author

Published In: Volume - 18, Issue - 3, Year - 2026

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ABSTRACT:
In 2024, India was estimated to have 1.56 million new cancer cases and 874,404 cancer deaths, according to a study by the Indian Council of Medical Research (ICMR). In recent years, nanoparticles have drawn a lot of interest as a promising drug delivery system to address this challenge, particularly for the treatment of cancer. Nanoparticles, or particles with a size of roughly 10 to 100 nanometers, have the potential to be especially effective agents in the detection, diagnosis, and treatment of cancer because of their size and supramolecular structures. The study describes how different nanoparticles—such as liposomes, polymeric nanoparticles, dendrimers, and magnetic nanoparticles—are used for targeted drug delivery. When compared to conventional therapy, these nanoparticledrug formulations can improve the safety, pharmacokinetic profiles, and bioavailability of the administered drugs, resulting in increased therapeutic efficacy. Nanomedicine products represent an opportunity to achieve sophisticated targeting Strategies and multifunctionality. Azadirachta indica (neem), a medicinal plant with a well-documented history in Ayurvedic medicine, is a rich source of bioactive limonoids possessing potent anticancer properties. This review comprehensively examines the convergence of neem phytochemistry and nanotechnology, focusing on the green synthesis of neem-based nanoparticles (NPs) and their multifaceted mechanisms against cancer. We elaborate on the efficacy of various neem NPs, including silver, gold, zinc oxide, and polymeric NPs, in inducing apoptosis, generating reactive oxygen species (ROS), inhibiting metastasis, and modulating key oncogenic pathways. Discusses the current challenges, and presents future perspectives for the clinical translation of neem nanoparticles as a cornerstone of integrative oncology. This study explores a novel herbal drug delivery system utilizing neem nanoparticles for the targeted delivery of anticancer compounds, enhancing therapeutic efficacy.

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Cite this article:
Vaishnavi Ashok Gore. A Review on Neem Nanoparticles used in Cancer Therapy. Research Journal of Science and Technology. 2026; 18(3):274-8. doi: 10.52711/2349-2988.2026.00038

Cite(Electronic):
Vaishnavi Ashok Gore. A Review on Neem Nanoparticles used in Cancer Therapy. Research Journal of Science and Technology. 2026; 18(3):274-8. doi: 10.52711/2349-2988.2026.00038 Available on: https://rjstonline.com/AbstractView.aspx?PID=2026-18-3-5

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