Author(s):
Sulochana Dutta, B. Ray, Shibani Raut, C. K. Sahoo
Email(s):
dutta.sulochana2000@gmail.com
DOI:
10.5958/2349-2988.2021.00003.6 
Address:
Sulochana Dutta1, Dr. B. Ray2, Shibani Raut1, Dr. C. K. Sahoo3
15th Sem Gayatri College of Pharmacy
2Associate Prof, Gayatri College of Pharmacy
3Dept. of Pediatric SCB Medical College, Cuttack.
*Corresponding Author
Published In:
Volume - 13,
Issue - 1,
Year - 2021
ABSTRACT:
The opportunities for gene delivery using non-viral delivery systems seem to be abundant and the ultimate goal of providing tailor-made individualized medicines seems to be a very bright prospect indeed. Apart from intracellular and extracellular barrier number of other challenges are need to be over come in order to increase the effectiveness of nonviral gene transfer. This present review highlights the different aspects of Non viral Vector mediated gene therapy.
Cite this article:
Sulochana Dutta, B. Ray, Shibani Raut, C. K. Sahoo. Nonviral Gene Therapy: Technology and Application. Research J. Science and Tech. 2021; 13(1):13-22. doi: 10.5958/2349-2988.2021.00003.6
Cite(Electronic):
Sulochana Dutta, B. Ray, Shibani Raut, C. K. Sahoo. Nonviral Gene Therapy: Technology and Application. Research J. Science and Tech. 2021; 13(1):13-22. doi: 10.5958/2349-2988.2021.00003.6 Available on: https://rjstonline.com/AbstractView.aspx?PID=2021-13-1-3
REFERENCES:
1. Textbook of pharmaceutical biotechnology Vyas and Dixit chapter Drug Delivery System in Gene therapy.
2. Groneberg D.A, WiHC., Wagner U., Chung K.F., Fisher A. Fundamentals of pulmonary drug delivery. Respir . Med . 2003; 97: 382-387 . doi :10.1053/rmed.2002.1457.
3. Gardlik R, Palffy R, Hodosy J, Lukacs J, Turna J, Celec P. Vectors and delivery systems in gene therapy. Med Sci Monit. 2005.11:110-121.
4. Huang Y, Liu X, Dong L, Liu Z, He X, Liu W. Development of viral vectors for Gene Therapy for Chronic pain. Pain Res Treat . 2011; 2011: 968218.
5. Newmann E, Schaefer-Ridder M, Wang Y, Hofschneider PH Gene transfer into mouse lyoma cells by electroporation in high electric field . Embo J . 1982 1(7):841-5.
6. Metallic nano particles Dragomir Minela (pdf) , University of Nova Gonica , doctoral study, programme physics).
7. Wang W, Li W, Ma N, Steinhoff G. Non-viral gene delivery methods. Curr Pharm Biotechnol. 2013;14(1):46-60.
8. S . Kawakami , Y . Higachi, M . Hashida – journal of pharmaceutical science , 2008 Elsevier.
9. Shirley S , Heller R, Heller L. In Gene therapy of cancer. 3rd edition. Sandiego [USA]: Elsevier; 2013. Electroporation gene therapy ; pp . 93-106. Edited by lattime EC, Gerson SL.
10. Kossovsky, N; Gelman, A; Sponsler, EE; Hnatyszyn, AJ.; Rajguro, S.; Torres, M.; Pham, M .;Crowder, J.;Zemanovich, J.; Chung, A and Shah, R “Surface modified nanocrystalline ceranlic for drug delivery applications.” Biomaterials ,(1994a) 15: 1201-1207.
11. Kircheis R, Kichler A, Wallner G, Kursa M,Ogris M, Felzmann T, et al. Coupling of cell binding ligands to polyethylenimine for targeted gene delivery. Gene Ther. 1997;4:409-18.
12. Gao X, Huang L. Potentiation of cationic liposome-mediated gene delivery by polucationics. Biochemistry . 1996;35:1027-36.
13. Lundstrom K, Boulikas T. Viral and non viral vectors in gene therapy: Technology development and clinical trials. Technol Cancer Res Treat. 2003;5(2):471-85.
14. Morishital, et al. Phase I/IIa clinical trial of therapeutic angiogenesis using hepatocyte growth factor gene transfer to treat critical limb ischemia. Arterioscler Thromb Vasc Biol. 2011;31:713-20.