Author(s): M. Surendra, T. Venkateswara Rao

Email(s): msurendra51@gmail.com

DOI: Not Available

Address: M. Surendra* and T. Venkateswara Rao
Department of pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (D.t), Andhra Pradesh
*Corresponding Author

Published In:   Volume - 4,      Issue - 1,     Year - 2012


ABSTRACT:
Solid dispersion is the science of dispersing one (or) more active ingredients in an inert carriers (or) matrix at solid state prepared by melting solvent method (or) solvent evaporation method. Sparingly water soluble drugs often show an erratic dissolution profile in gastrointestinal fluids which consequently results variable oral bio-availability. To improve the dissolution and bioavailability of these drugs, various techniques such as solvent evaporation method, melting method, super critical fluid process, spray drying, lyophilisation, melt agglomeration, extrusion kneading method. The various inert carriers such as acids, polymeric materials, insoluble (or) enteric polymers, surfactants etc. PEG, PVP, lactose, Mannitol, Cyclodextrins and HPMC were used to increased solubility. Solid dispersions were prepared by solvent evaporation method. Solid dispersions of ibuprofen were prepared to increase its aqueous solubility using carriers such as mannitol, urea, and sorbitol. Ibuprofen solid dispersions were prepared in 1:1, 1:2 and 1:3 ratios of the drug to carriers (w/w). The prepared solid dispersion were evaluated for physical parameters like Angle of repose, Bulk density, Carr’s index, Hausner ratio and Invitro drug release studies. Invitro drug release profile of solid dispersions were comparatively evaluated and also studied against pure Ibuprofen. Higher dissolution rate were exhibited by solid dispersions containing 1:3 ratio of Ibuprofen with urea, the rate of drug release was depended on the type, ratio of drug to carrier and method of dispersions.


Cite this article:
M. Surendra, T. Venkateswara Rao. Formulation and Evaluation of Ibuprofen Solid-Dispersions Prepared by Solvent Evaporation Technique. Research J. Science and Tech. 2012; 4(1): 22-27 .


Recomonded Articles:

Author(s): Debjit Bhowmik, K.P. Sampath Kumar, Lokesh Deb

DOI: 10.5958/2349-2988.2016.00012.7         Access: Closed Access Read More

Author(s): Bhushan A. Bhairav, Prajakta A. Kokane, Ravindra B. Saudagar

DOI: 10.5958/2349-2988.2016.00022.X         Access: Closed Access Read More

Author(s): Debjit Bhowmik, Rishab Bhanot, Darsh Gautam, Parshuram Rai, K. P. Sampath Kumar

DOI: 10.5958/2349-2988.2018.00022.0         Access: Open Access Read More

Author(s): M. Surendra, T. Venkateswara Rao

DOI:         Access: Open Access Read More

Author(s): Mukesh K. Nag, Satish Patel, Shikha Shrivastava, S.J. Daharwal, Manju R. Singh, Deependra Singh

DOI:         Access: Open Access Read More

Author(s): Sirisha Y. , Venkateswara Rao T.

DOI:         Access: Open Access Read More

Author(s): Gaikwad Bhaskar G, Dwivedy Kritika R.

DOI: 10.5958/2349-2988.2016.00007.3         Access: Open Access Read More

Author(s): Dron P. Modi, Dhrubo Jyoti Sen

DOI:         Access: Open Access Read More

Author(s): S. D. Mankar, Anjali Dama, M. S. Bhosale, Dr. S. S. Sidhheshwar

DOI: 10.5958/2349-2988.2020.00011.X         Access: Closed Access Read More

Research Journal of Science and Technology (RJST) is an international, peer-reviewed journal, devoted to science and technology...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2349-2988 


Recent Articles




Tags