Author(s): Najwa Sh Ahmed, Yasmin Ali Hadi, Iqbal Hanash Dhefer

Email(s): iqbal_defer@yahoo.com , iqbal.hanash@instituteofsuwaria.com

DOI: 10.5958/2349-2988.2019.00001.9   

Address: Najwa Sh Ahmed1, Yasmin Ali Hadi1, Iqbal Hanash Dhefer2*
1Biotechnology Research, Molecular, and Biotechnology Laboratory, AL-Nahrain University, Baghdad, Iraq
2Nursing Department, AL-Suwaira Technical Institute, Middle Technical University
*Corresponding Author

Published In:   Volume - 11,      Issue - 1,     Year - 2019


ABSTRACT:
Transcription factor7 like 2 gene (TCF7L2) genomic polymorphisms are scanned to be powerfully related to diabetes mellitus type 2 (DM2) in female Iraqi population. The goal of this paper was to analyze the correlation of TCF7L2 gene polymorphisms with DM2 in a very female public of AL- Iraq. Techniques: 70 DM2 female patients and 60 healthy samples were chosen for the current study. Has been conducted designedly of one primer for amplification to scan the gene and using PCR technique with sequencing. We tend to measure the concentration of blood urea nitrogen, triglyceride total cholesterol, low density lipoprotein, high density lipoprotein, fasting glucose and creatinine in serum by utilizing equipment for chemical examination. Results: For total participants, the (G/A vs. AG + GT) were significantly greater in samples with DM2 than in healthy controls, and following some factors, like serum concentration of TC, TG, LDL, and HDL for DM2, the difference in significant was found. This result revealed that the risk of DM2 was raised with the existence of the GA and GT genotype of TCF7L2 gene in Iraqi female. The G allele frequency of TCF7L2 gene was greater in DM2 patients than in healthy control samples. Conclusions: Our analysis proposed that the TCF7L2 gene genetic polymorphisms were related with DM2 in the female populace of Iraq.


Cite this article:
Najwa Sh Ahmed, Yasmin Ali Hadi, Iqbal Hanash Dhefer. Polymorphism Study of TCF7L2 gene and related to some biochemical parameters in DM2 females Iraqi patients. Research J. Science and Tech. 2019; 11(1):01-08. doi: 10.5958/2349-2988.2019.00001.9


Recomonded Articles:

Author(s): Edokwe Chinelo, Obidoa Onyechi, Joshua Parker Elijah

DOI:         Access: Open Access Read More

Author(s): Srikanta Chowdhury, Md. T.A. Chowdhury, Md. Golam Kabir, Dwaipayan Sikdar, Aninda Kumar Nath, Md. Zia Uddin, Dibyajyoti Saha

DOI:         Access: Open Access Read More

Author(s): Najwa Sh Ahmed, Yasmin Ali Hadi, Iqbal Hanash Dhefer

DOI: 10.5958/2349-2988.2019.00001.9         Access: Closed Access Read More

Author(s): Tianxin Sheng, Yunhe Lu, Kangjuan Yang, Yan Jin, Yinghua Wu, Zibo Zhang, YanhuaJin, XiongjiJin

DOI: 10.5958/2349-2988.2016.00004.8         Access: Open Access Read More

Author(s): Srikanta Chowdhury, Md. T. A. Chowdhury, Md. Golam Kabir, Dwaipayan Sikdar, Aninda Kumar Nath, Md. Zia Uddin, Dibyajyoti Saha

DOI:         Access: Open Access Read More

Author(s): T. Murugan, U.S. Mahadeva Rao

DOI:         Access: Open Access Read More

Research Journal of Science and Technology (RJST) is an international, peer-reviewed journal, devoted to science and technology...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2349-2988 


Recent Articles




Tags