Ali Adel Dawood, Zeyad Thanoon Al-Rrassam, Mahmood Abduljabar Altobje
firstname.lastname@example.org , email@example.com , firstname.lastname@example.org
Ali Adel Dawood1, Zeyad Thanoon Al-Rrassam2, Mahmood Abduljabar Altobje3
1Department of Anatomy, College of Medicine, University of Mosul, Mosul, Iraq.
2Department of Biophysics, College of Science, University of Mosul, Mosul, Iraq.
3Department of Biology, College of Science, University of Mosul, Mosul, Iraq.
Volume - 14,
Issue - 1,
Year - 2022
Questions that come to mind about the true genetic origin of the novel coronavirus and its direct source. As it is likely that these questions will be answered through aspects of the relationship between science and intelligence, the results of which will converge together in the end to some evidence. Materials and methods: The 29 complete coronavirus and HIV genomes were collected from various countries at random and conducted various bioinformatics instruments in order to find connections between viral sequences from various sources. Results: The closest similarity between the SARS-CoV-2 genomes approximately (99.98%). The small difference between genome sequences is considered as weak mutations occur even at the present time. This study revealed that the novel coronavirus had a structure identical to the HIV virus which it reached approximately 46.33%. Conclusions: It is not possible for the SARS-CoV-2 to be related to HIV through mutation, manipulation, or laboratory artificial. Laboratory mutation occurred in the Wuhan lab and led to the outbreak of the epidemic, deliberately or accidentally, and this will be determined later.
Cite this article:
Ali Adel Dawood, Zeyad Thanoon Al-Rrassam, Mahmood Abduljabar Altobje. Did the SARS-CoV-2 Come from Wild, Mutagenic or Artificial Type? Complete Genome Analysis. Research Journal of Science and Technology. 2022; 14(1):21-9. doi: 10.52711/2349-2988.2022.00003
Ali Adel Dawood, Zeyad Thanoon Al-Rrassam, Mahmood Abduljabar Altobje. Did the SARS-CoV-2 Come from Wild, Mutagenic or Artificial Type? Complete Genome Analysis. Research Journal of Science and Technology. 2022; 14(1):21-9. doi: 10.52711/2349-2988.2022.00003 Available on: https://rjstonline.com/AbstractView.aspx?PID=2022-14-1-3
1. Prathmesh, J., Manohar, K., Ravina, J., Aishwarya, S., Shweta, K., and Honmane, P. On overview- Corona virus and Hanta virus Disease. Asian Journal of Research and Pharmacological Science. 2020; 10(3):178-182.
2. Smith, W., and Freedman, DO. Isolation, quarantine, social distancing, and community containment: a pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak. Journal of Travel Medicine. 2020; 13; 27(2),1–4.
3. Young, BE., Ong, S., Kalimuddin, S., Low, JG., Tan, SY., Loh, J., et al. (2020). Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore. JAMA, Mar. 3. https://doi.org/10.1001/jama.2020.3204.
4. Michelle, L., Zh, Q., De, D., Qin, X., Warren, L., and Wee, Y. (2020). A tale of two cities: a comparison of Hong Kong and Singapore's early strategies for the Coronavirus Disease 2019 (COVID-19). The Journal of Infection, S0163-4453(20)30439-4. https://doi.org/10.1016/j.jinf.2020.06.058.
5. Dawood, A., and Altobje, M. (2020). Precautionary measures are taken by countries to reduce the transmission of the COVID-19. Asian Journal of Advances in Medical Science, 2(2):29-32.
6. World Health Organization. (2020). SARS-CoV-2 mink-associated variant strain – Denmark. Nov. 6. https://www.who.int/csr/don/06-november-2020-mink-associated-sars-cov2-denmark/en/.
7. Paiman, A. (2020). Leading Quarantines in the Time of COVID-19 Case Raparin-Area Kurdistan Region of Iraq, Rawand ESA. JMIR Preprints, 07/04/2020:19175. https://doi.org/10.2196/preprints.19175.
8. Dawood, A., Altobje, M. (2020). Inhibition of N-linked Glycosylation by Tunicamycin May Contribute to The Treatment of SARS-CoV-2. Microbial Pathogenesis, 149:104586. https://doi.org/10.1016/j.micpath.2020.104586.
9. Srinivasan, S., Cui, H., Gao, Z., Liu, M.,Lu, S., Mkandawire, W., Narykov, O., Sun, M., and Korkin, D. (2020). Structural Genomics of SARS-CoV-2 Indicates Evolutionary Conserved Functional Regions of Viral Proteins. Viruses, 12, (360). https://doi:10.3390/v12040360.
10. Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., et al. (2020). Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020: https://doi.org/10.1001/jama.2020.1585.
11. Vankadari N, and Wilce JA. Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26. Emr.Mic.Inf. 2020): Vol.9. https://doi.org/10.1080/22221751.2020.1739565.
12. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. (2020). Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA, 2020: https://doi.org/10.1001/jama.2020.1585.
13. Andersen, G., Rambaut, A., Lipkin, I., Holmes, C., and Garry, F. (2020). The proximal origin of SARS-CoV-2. Nature Medicine, 26, 450–452. https://doi:10.1038/s41591-020-0820-9.
14. Shen, Z., Xiao, Y., Kang, L., Ma, W., Shi, L., Zhang, L. et al. (2020). Genomic diversity of SARS-CoV-2 in coronavirus disease 2019 patients. Clinical Infection Disease, ciaa203. https://doi:10.1093/cid/ciaa203.
15. Dawood, A. (2020). Mutated COVID-19, May Foretells Mankind in a Great Risk in The Future. New Microbes and new Infections, (35): 100673. https://doi.org/10.1016/j.nmni.2020.100673.
16. Fung, T., and Liu, D. (2020). Coronavirus infection, ER stress, apoptosis and innate Immunity. Frontiers in Microbiology, 5(296). https://doi:10.3389/fmicb.2014.00296.
17. Manisha, R., Pradnya, K. (2020). Coronavirus Disease: A Review of a New Threat to Public Health. Asian J. Pharm. Res. 2020; 10(3):241-244.
18. Wrap D., Wang N., Corbett K.S., Goldsmith J.A., Hsieh C-L., Abiona O., Graham B.S., and McLellan S.J. Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation. Science, 367(6483):1260-1263. https://doi.org/10.1101/2020.02.11.944462.
19. Dawood, A., Alnori, H. (2020). Tunicamycin Anticancer Drug May Reliable to Treat Coronavirus Disease-19. Open Access Macedonian Jjournal of Medical Sciences, 8(T1):129-133. https://doi.org/10.3889/oamjms.2020.4954.
20. Wan, Y., Shang, J., Graham, R., Baric, RS., Li, L. (2020). Receptor recognition by a novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS. Journal of Virology, 94: (7) e00127-20. https://doi.org/10.1128/JVI.00127-20.
21. Cubuk, H., and Ozbil, M. (2020). Comparison of Clinically Approved Molecules on SARS-CoV-2 Drug Target Proteins: A Molecular Docking Study. ChemRxiv, https://doi.org/10.26434/chemrxiv.12090828.v1.
22. Dawood A, Altobje M, and Alnori H. Compatibility of the Ligand Binding Sites in the Spike Glycoprotein of COVID-19 with those in the Aminopeptidase and the Caveolins 1, 2 Proteins. Res J Pharm Tech. 2021; 14(9): 4760-4766. doi:10.52711/0974-360X.2021.00828. https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-42.
23. World Travel Guide. (2020). Can you travel safely when Coronavirus (COVID-19) is spreading fast? 2020;https://www.worldtravelguide.net/features/feature/can-you-travel-safely-when-coronavirus-covid-19-is-spreading-fast/.
24. Hafi, B., Uvais, N., Jafferany, M., Afra, T., and Ramzi, T. (2020). Can COVID-19 virus be transmitted through sex? Dermatologic Therapy, https://doi:10.1111/dth.13679.
25. Dawood, A. Transmission of SARS CoV-2 virus through the ocular mucosa worth taking precautions. Vacunas. 22(1):56–57. https://doi.org/10.1016/j.vacun.2020.09.003.
26. Mayur S. Jain, Shashikant D. Barhate. Corona viruses are a family of viruses that range from the common cold to MERS corona virus: A Review. Asian J. Res. Pharm. Sci. 2020; 10(3):204-210.
27. Ali A. Dawood. The Russian Vaccine of COVID-19 (Sputnik V) has shown side effects on the Volunteers. Asian Journal of Research in Pharmaceutical Sciences. 2021; 11(3):193-4.
28. Ritik S. Jain, Tejas G. Jain, Suraj K. Ishikar. Impact of Covid-19 on Changing Habits and Health Issues of the Public. Asian Journal of Management. 2020;11(4):524-528.