Author(s): Kushal Ramdas Landge, Suhas Siddheshwar, Rajashree Ghogare

Email(s): Kushal.landge555@gmail.com

DOI: 10.5958/2349-2988.2020.00029.7   

Address: Kushal Ramdas Landge1*, Dr Suhas Siddheshwar2, Rajashree Ghogare2
1Research Scholar, M Pharmacy, Pravara Rural College of Pharmacy, Pravaranagar.
2Assistant Professor, Pravara Rural College of Pharmacy, Pravaranagar.
*Corresponding Author

Published In:   Volume - 12,      Issue - 3,     Year - 2020


ABSTRACT:
Ramipril is a potent long acting ACE inhibitor and Hydrochlorothiazide is a thiazide diuretic and an antihypertensive. In literature few analytical methods are discussed for the estimation of Ramipril and Hydrochlorothiazide. The objective of this study is to develop and validate RP-HPLC method for the qualitative estimation of the drug. In most of the methods, the isocratic elution was carried out by using Acetonitrile, water and buffer as a mobile phase. The wavelength was in between 210 to 215nm for Ramipril and 316nm for Hydrochlorothiazide. The flow rate was approximately 0.8ml/min to 1.0ml/min. The temperature set was ambient temperature. The developed methods were validated as per ICH guidelines and this method were found to be specific, precise, sensitive and robustness.


Cite this article:
Kushal Ramdas Landge, Suhas Siddheshwar, Rajashree Ghogare. Analytical Method Development and Validation of Ramipril and Hydrochlorothiazide- A Review. Research J. Science and Tech. 2020; 12(3):211-221. doi: 10.5958/2349-2988.2020.00029.7


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