Piper nigrum (family Piperaceae) is a valuable medicinal plant. It is one of the most commonly used spices and considered as “The King of spices” among various spices. Black pepper is grown in many tropical regions like Brazil, Indonesia and India. Hot and pungent peppercorns are obtained from Black pepper which is the most famous and one of the commonly used spices throughout the world. Pepper is used worldwide in different types of sauces and dishes like meat dishes. One study reported that piperine is widely used in various herbal cough syrups for its potent anti-tussive and bronchodilator properties. It is used in anti- inflammatory, anti-malarial, anti-leukemia treatment. Recent medical studies have shown that it is helpful in increasing the absorption of certain vitamins, selenium, ß-cartene, also increase the body’s natural thermogenic activity.
Cite this article:
Pal Neha, Joshi M. D. Piper nigrum: An Overview of effects on Human Health. Research J. Science and Tech. 2020; 12(4):331-337. doi: 10.5958/2349-2988.2020.00050.9
1. Taqvi, S.I., Shah, A.J., and Gilani, A.H. 2008. Blood pressure lowering and vasomodulator effects of piperine. J. Cardiovasc. Pharmacol. 52: 452-458.
2. Manoharan, S., Balakrishnan, S., Menon, V., Alias, L., and Reena, A. 2009. Chemopreventive efficacy of curcumin and piperine during 7, 12- dimethylbenz [a] anthracene-induced hamster buccal pouch carcinogenesis. Singapore Med. J. 50: 139-46.
3. Parganiha, R., Verma, S., Chandrakar, S., Pal, S., Sawarkar, H.A., and Kashyap, P. 2011. In vitro anti- asthmatic activity of fruit extract of Piper nigrum (Piperaceae). Inter. J. Herbal. Drug. Res. 1:15-18.
4. Li, S., Wang, C., Wang, M., Li, W., and Matsumoto, K. 2007. Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life Sci. 80: 1373- 1381.
5. Matsuda, H., Ninomiya, K., Morikawa, T., Yasuda, D., and Yamaguchi, I. 2008. Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-alpha-induced cell death in mouse hepatocytes. Bioorg. Med. Chem. Lett. 18: 2038-2042.
6. Johnson, J.J., Nihal, M., Siddiqui, I.A., Scarlett, C.O., and Bailey, H.H. 2011. Enhancing the bioavailability of resveratrol by combining it with piperine. Mol. Nutr. Food. Res. 55: 1169-1176.
7. Wattanathorn, J., Chonpathompikunlert, P., Muchimapura, S., Priprem, A., and Tankamnerdthai, O. 2008. Piperine, the potential functional food for mood and cognitive disorders. Food. Chem. Toxicol. 46: 3106-3110.
8. Majeed, M., Badmeev, V., and Rajendranm R. 1999. Use of piperine as a bioavailability enhancer. United States Patent. 5: 972,382.
9. Parmar, V.S., Jain, S.C., Bisht, K.S., Jain, R., Taneja, P., Jha, A. 1997. Phytochemistry of the genus Piper. Phytochemistry. 46: 597-673.
10. Khan, M., and Siddiqui, M. 2007. Antimicrobial activity of Piper fruits. Nat. Prod. Rad. 6: 111-113.
11. Kumar, K.P., Gnanajobitha, G., Vanaja, M., Kumar, S.R., Malarkodi, C., and Pandian, K. 2014. Piper nigrum Leaf and Stem Assisted Green Synthesis of Silver Nanoparticles and Evaluation of its Antibacterial Activity against Agricultural Plant Pathogens. Scientific World Journal. 829- 894.
12. Vijayakumar, R.S., Surya, D., and Nalini, N. 2004. Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress. Redox. Rep. 9: 105-110.
13. Ahmad, N., Fazal, H., Abbasi, B.H., Rashid, M., Mahmood, T., and Fatima, N. 2010. Efficient regeneration and antioxidant potential in regenerated tissues of Piper nigrum L. Plant Cell, Tissue and Organ Culture. Plarma. Res. 102: 129-134.
14. Hritcu, L., Noumedem, J.A., Cioanca, O., Hancianu, M., and Kuete, V. 2014. Methanolic extract of Piper nigrum fruits improves memory impairment by decreasing brain oxidative stress in amyloid beta (1-42) rat model of Alzheimer’s disease. Cell. Mol. Neurobiol. 34: 437- 449.
15. Agbor, G.A., Akinfiresoye, L., Sortino, J., Johnson, R., and Vinson, J.A. 2012. Piper species protect cardiac, hepatic and renal antioxidant status of atherogenic diet fed hamsters. Food. Chem. 134: 1354-1359.
16. Hussain, A., Naz, S., Nazir, H., and Shinwari, Z.K. 2011.Tissue culture of Black pepper (Piper nigrum L.) in Pakistan. Pak. J. Bot. 43: 1069-1078.
17. Selvendiran, K., and Sakthisekaran, D. 2004. Chemopreventive effect of piperine on modulating lipid peroxidation and membrane bound enzymes in benzo (a) pyrene induced lung carcinogenesis. Biomed. Pharmacother. 58: 264-267.
18. Doucette, C.D., Hilchie, A.L., Liwski, R., and Hoskin, D.W. 2013. Piperine, a dietary phytochemical, inhibits angiogenesis. J. Nutr. Biochem. 24: 231- 239.
19. Makhov, P., Golovine, K., Canter, D., Kutikov, A., and Simhan, J. 2012. Coadministration of piperine and docetaxel results in improved anti-tumor efficacy via inhibition of CYP3A4 activity. Prostate. 72: 661-667.
20. Samykutty, A., Shetty, A.V., Dakshinamoorthy, G., Bartik, M.M., Johnson, G.L., and Webb, B. 2013. Piperine, a bioactive component of pepper spice exerts therapeutic effects on androgen dependent and androgen independent prostate cancer cells. PLoS. One. 8: e65889.
21. Srinivasan, K. 2007. Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit. Rev. Food. Sci. Nutr. 47: 735- 748.
22. Bang, J.S., Oh da, H., Choi, H.M., Sur, B.J., and Lim, S.J. 2009. Anti- inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis. Res. Ther. 11: R49.
23. Nirwane, A.M., and Bapat, A.R. 2012. Effect of methanolic extract of Piper nigrum fruits in Ethanol-CCl4 induced hepatotoxicity in Wistar rats. Der. Pharmacia. Lettre. 4: 795-802.
24. Shamkuwar, P.B., Shahi, S.R., and Jadhav, S.T. 2012. Evaluation of antidiarrhoeal effect of Black pepper (Piper nigrum L). Asian Journal of Plant Science and Research. 2: 48-53.
25. Platel, K., and Srinivasan, K. 1996. Influence of dietary spices or their active principles on digestive enzymes of small intestinal mucosa in rats. Int. J. Food. Sci. Nutr. 47: 55-59.
26. Platel, K., and Srinivasan, K. 2000. Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats. Nahrung. 44: 42-46.
27. Platel, K. and Srinivasan, K. 2001. Studies on the influence of dietary spices on food transit time in experimental rats. Nutr. Res. 21: 1309-14.
28. Mao, Q.Q., Huang, Z., Zhong, X.M., Xian, Y.F., and Ip, S.P. 2014. Piperine reverses the effects of corticosterone on behavior and hippocampal BDNF expression in mice. Neurochem. Int. 74: 36-41.
29. Sunila, E.S., and Kuttan, G. 2004. Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. J. Ethnopharmacol. 90: 339- 346.
30. Sharma, S., Kalia, N.P., Suden, P., Chauhan, P.S., and Kumar, M. 2014. Protective efficacy of piperine against Mycobacterium tuberculosis. Tuberculosis (Edinb.). 94: 389-396.
31. Chen, C.Y., Li, W., Qu, K.P., and Chen, C.R. 2013. Piperine exerts anti- seizure effects via the TRPV1 receptor in mice. Eur. J. Pharmacol. 714: 288-294.
32. Bukhari, I.A., Pivac, N., Alhumayyd, M.S., Mahesar, A.L., and Gilani, A.H. 2013. The analgesic and anticonvulsant effects of piperine in mice. J. Physiol. Pharmacol. 64: 789-794. Pourabbas, S., Kesmati, M., and Rasekh, 2011. Study of the the anxiolytic effects of fennel and possible roles of both gabaergic system and estrogen receptors in these effects in adult female rat. Physiol. Pharmacol. 15(1): 134-43.
33. Mesfin, M., Asres, K., and Shibeshi, W. 2014. Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare Miller in mice. BMC Complement. Altern. Med. 14(1): 310.