Author(s): Atul Bajaj, Cijo John, Joydip Choudhury, Rohitashva Mani Tripathi

Email(s): atulbajaj37@gmail.com

DOI: 10.5958/2349-2988.2017.00055.9   

Address: Atul Bajaj*, Cijo John, Joydip Choudhury, Rohitashva Mani Tripathi
Central Forensic Science Laboratory, Plot No 2, Sector 36 A, Dakshin Marg, Ministry of Home Affairs, Govt. of India, Chandigarh, India-160036
*Corresponding Author

Published In:   Volume - 9,      Issue - 3,     Year - 2017


ABSTRACT:
The present work describes a method for simultaneous determination of four p-hydroxy benzoates (parabens) preservatives in cosmetics, personal care and pharmaceuticals formulations. The method blends liquid-liquid extraction and gas chromatography mass spectrometry in electron impact ionization positive mode. The various influencing parameters were optimized and validated. Chromatographic separation was achieved on BP-5 capillary column with short run time of 8.13 minutes. Linearity of the method was excellent for all analytes with regression coefficient values (R2) > 0.993. The method was successfully applied to commercially available formulations. The developed method can be used in routine every day analysis by testing and quality control laboratories.


Cite this article:
Atul Bajaj, Cijo John, Joydip Choudhury, Rohitashva Mani Tripathi. Development and Validation of Gas Chromatography/Mass Spectrometry Method for the Simultaneous Determination of Some Preservatives in Personal Care, Cosmetics and Pharmaceutical Formulations. Research J. Science and Tech. 2017; 9(3): 308-312. doi: 10.5958/2349-2988.2017.00055.9


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