Author(s): Chaskar Swati G., Avhad Pawan S.

Email(s): swatichaskar55@gmail.com , pawanavhad@gmail.com

DOI: 10.5958/2349-2988.2020.00017.0   

Address: Chaskar Swati G., Avhad Pawan S.
Matoshri Institute of Pharmacy, Dhanore, Yeola, Nashik, 423401.
*Corresponding Author

Published In:   Volume - 12,      Issue - 2,     Year - 2020


ABSTRACT:
A new simple, precise, sensitive, RP-HPLC method was developed for the estimation of Esmolol Hydrochloride in bulk and injection. The ?max for Esmolol Hydrochloride was found to be 224nm. The linearity in the concentration range of 10µg/ml to 50µg/ml (r2=0.998). The chromatographic values for Esmolol Hydrochloride were found to be satisfactory on BDS Hypersil Grace C18, 250mm x 4.6ID, 5µm, column using mobile phase of ACN: Buffer in the ratio of 80:20 v/v, pH 3 with the flow rate of 0.8ml/min. Retention time of drug was 5.593 min. The limit of detection and limit of quantification was 0.4638µg/ml and 1.4055µg/ml respectively. The developed method was validated according to ICH guidelines and found to be accurate, precise, robust and good in accordance with the prescribed values. Degradation study of drug is also done. The newly developed method can be used for routine analysis estimation of Esmolol Hydrochloride in bulk and dosage form in pharmaceutical industry.


Cite this article:
Chaskar Swati G., Avhad Pawan S. Stability Indicating RP-HPLC Method Development and Validation of Esmolol in Bulk and Injection. Research J. Science and Tech. 2020; 12(2): 136-142. doi: 10.5958/2349-2988.2020.00017.0


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