Gymnema sylvestre is a plant included in Apocynaceae family and is located in many regions of Asia, Africa and Australia. It is known to have blood glucose lowering potential and, thus, is widely used in traditional and Ayurvedic systems of medicine. A scrutiny of literature revealed some notable pharmacological activities of the plant such as antidiabetic, antiobesity, hypolipidaemic, antimicrobial, free radical scavenging and anti-inflammatory. The phytoconstituents responsible for sweet suppression activity includes triterpene saponins known as gymnemic acids, gymnemasaponins, and a polypeptide, gurmarin. Efforts have been made to prepare gudmar dried extract. These extracts were subjected for preliminary qualitative analysis, quantitative estimation of terpenoides, alkaloids and various other compounds. The present review is an attempt to highlight the phytochemical screening as well as its extraction process. Also chromatographic studies gave the presence of different compounds which can be used in creating monograph for this species.
Cite this article:
Sejal M. Karwa, Dattaprasad N. Vikhe, Ravindra S. Jadhav. A Review on Phytochemical Investigation of Gymnema sylvestre Leaves. Research Journal of Science and Technology. 2022; 14(4):261-8. doi: 10.52711/2349-2988.2022.00042
Sejal M. Karwa, Dattaprasad N. Vikhe, Ravindra S. Jadhav. A Review on Phytochemical Investigation of Gymnema sylvestre Leaves. Research Journal of Science and Technology. 2022; 14(4):261-8. doi: 10.52711/2349-2988.2022.00042 Available on: https://rjstonline.com/AbstractView.aspx?PID=2022-14-4-10
1. Giovanni DF, Valeria R, Cinzia DM, Antonio P, Armando Z. Gymnema sylvestre R. Br., an Indian medicinal herb: Traditional uses, chemical composition, and biological activity. Curr Pharm Biotechnol 2015;16:506-16.
2. Sabitha RA, Nagamani V, Patnaik S, Saidulu B. Gymnema sylvestre: An important anti diabetic plant of India: A review. Plant Sci Feed 2012;2:174-9.
3. Keshavamurthy KR, Yoganarasimhan SN. Flora of Coorg-Karnataka. Bangalore: Vimsat Publishers; 1990. p. 282.
4. Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 2002;81(1):81-100.
5. Subramaniyan V, Srinivasan P. Gymnema sylvestre-a key for diabetes management-a review. Biomed Res 2014;1(1):1-10.
6. Anonymous. The Wealth of India: Raw Materials. Vol. IV. New Delhi: Publication and Information Directorate, CSIR; 1956. p. 276-7
7. Kanetkar, P. Singhal, R. Kamat, M., Gymnema sylvestre: A Memoir. J Clin Biochem Nutr, 41: 77-81 (2007)
8. Kanetkar, P.V. Laddha, K.S. Kamat, M.Y., Gymnemic acids: A molecular perspective of its action on carbohydrate metabolism. Poster presented at the 16th ICFOST meet organized by CFTRI and DFRL, Mysore, India (2004)
9. Persaud, S.J. Majed, H.A. Raman, A. Jones, P.M., Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. J Endocrinol, 163: 207-212 (1999)
10. Nadkarni, K.M., Indian Materia Medica. Popular prakashan, Bombay, 596-9 (1993)
11. Vaidyaratnam, P., Indian Medicinal Plants. Orient Longman Publisher, Madras, 107-9 (1995)
12. Chopra, R.N. Nayar, S.L. Chopra, I.C., Glossary of Indian Medicinal Plants; [with] Supplement. Council of Scientific and Industrial Research, New Delhi, 319-22 (1992)
13. Selvanayagam, Z.E. Gnanavendhan, S.G. Chandhra Shekaran, P. Balakrishna, K. and Rao, R.B., Plants with antisnake venom activity- a review on pharmacological and clinical studies. Fitoterap, 65: 99-11 (1995)
14. Kapoor LD. Handbook of Ayurvedic Medicinal Plants. Boca Raton, FL: CRC Press, Inc.; 1990. p. 200-1.
15. Manni PE, Sinsheimer JE. Constituents from Gymnema sylvestre Leaves. J Pharm Sci 1965;54(10):1541-4.
16. Dateo GP Jr, Long L Jr. Gymnemic acid, the antisaccharine principle of Gymnema sylvestre. Studies on the isolation and heterogeneity of gymnemic acid A1. J Agric Food Chem 1973;21(5):899-903.
17. Srinivasan K, Kumaravel S. Unraveling the potential phytochemical compounds of Gymnema Sylvestre through Gc-Ms study. Int J Pharm Pharm Sci 2016;8(1):450-3.
18. Chakravarti D, Debnath NB. Isolation of gymnemagenin the sapogenin from Gymnema sylvestre R.Br. (Asclepiadaceae). J Inst Chem 1981;53:155-8.
19. Yoshikawa K, Amimoto K, Arihara S, Matsuura K. Structure studies of new anti-sweet constituents from Gymnema sylvestre. Tetrahedron Lett 1989;30(9):1103-6.
20. Yoshikawa K, Amimoto K, Arihara S, Matsuura K. Gymnemic acid V, VI and VII from gur-ma, the leaves of Gymnema sylvestre R.Br. Chem Pharm Bull 1989;37(3):852-4.
21. Imoto T, Miyasaka A, Ishima R, Akasaka K. A novel peptide isolated from the leaves of Gymnema sylvestre-I. Characterization and its suppressive effect on the neural responses to sweet taste stimuli in the rat. Comp Biochem Physiol A Comp Physiol 1991;100(2):309-14
22. Farzana C, Muhammad HR. Isolation and characterization of gymnemic acid from Indigenous gymnema sylvestr. Journal of Applied Pharmaceutical science, 2010; 3(2):60-65.
23. Killedar SG, Rathod AM, Salunkhe RM, Bhore NV, Mahamuni SS, Parameters studied for development of gymnema sylvestre leaf extracts: As injectable antidiabetic. International Journal of Research in Ayurveda and Pharmacy. 2012; 3(2):283-285.
24. Toshihiro Y, Kenzi M, Kenzo O, Osamu T. Quantitative analysis of gymnemic acids by high performance liquid chromatography. Nipp Shok Kag Kai 1994;41:202-5.
25. Anonymous. The Ayurvedic Pharmacopoeia of India, Government of India, Ministry of Health and Family welfare, Department of Ayush 2016; 9: 128.
26. Manohar SH, Naik PM, Praveen N, Murthy HN. Distribution of Gymnemic acid in various organs of Gymnema sylvestre. Journal of Forestry Research 20 (2009) 268−270. https://doi.org 10.20959/wjpr 201710-9267.