Author(s): S. Ramya Sri

Email(s): Email ID Not Available

DOI: 10.5958/2349-2988.2019.00003.2   

Address: S. Ramya Sri*
Department of Pharmaceutics, University of Technology, Osmania University, Hyderabad, Telangana
*Corresponding Author

Published In:   Volume - 11,      Issue - 1,     Year - 2019


ABSTRACT:
Emulsion cross linking method can be successfully employed to fabricate Nizatidine microspheres than Ionotropic gelation method. The technique provides characteristic advantage over conventional microsphere method, which involves an “all-aqueous” system, avoids residual solvents in microspheres. Other methods utilize larger volume of polymer, uneasy in dropping through syringe, air pollution, toxicity and difficult to remove traces during filtration. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers and copolymer used. Micromeritic studies revealed that the mean particle size of the prepared microspheres was in the size range 540µm to 644µm.Increase in the polymer concentration led to increase in % Yield, % Drug entrapment efficiency, Particle size, % swelling and % Mucoadhesion. The in-vitro mucoadhesive study demonstrated that microspheres of Nizatidine using chitosan as polymer and glutaraldehyde as cross linking agent adhered to the mucus to a greater extent than sodium alginate along with Carbopol934.The invitro drug release decreased with increase in the polymer and copolymer concentration.


Cite this article:
S. Ramya Sri. Formulation and Evaluation of Nizatidine Microspheres. Research J. Science and Tech. 2019; 11(1):14-26. doi: 10.5958/2349-2988.2019.00003.2


Recomonded Articles:

Author(s): Leena Sahu, Amit Roy, Trilochan Satapathy

DOI:         Access: Open Access Read More

Author(s): Kanimozhi K*. Panneerselvam A.

DOI:         Access: Open Access Read More

Author(s): A. Mahesh, P. Durga Prasad, C.S.K. Raju, P. Prakash, S.V.K. Varma

DOI: 10.5958/2349-2988.2018.00012.8         Access: Open Access Read More

Author(s): K. Venkateswara Raju, C.S.K. Raju, B. Mamata, M.C. Raju

DOI: 10.5958/2349-2988.2017.00097.3         Access: Open Access Read More

Author(s): Prerana H. Salodkar, Nikhil A. Maske, Dipali H. Chaudhari

DOI: 10.5958/2349-2988.2015.00032.7         Access: Open Access Read More

Author(s): Ch. Murali Krishna, K. R. Sekhar, C.S.K. Raju, G. V. Reddy, P. Prakash

DOI: 10.5958/2349-2988.2017.00098.5         Access: Open Access Read More

Author(s): Harshal Patil, Pawan Meshram, Jyotsna Waghmare

DOI:         Access: Open Access Read More

Author(s): B. Madhusudhana Rao1*, V. Nagendramma2, C.S.K. Raju3, A. Leelaratnam4, P. Prakash5;

DOI: 10.5958/2349-2988.2017.00096.1         Access: Open Access Read More

Author(s): R.V.S. Prasad

DOI: 10.5958/2349-2988.2017.00101.2         Access: Open Access Read More

Author(s): Pravin A. Dhakite, B. B. Gogte, B. W. Phate

DOI:         Access: Open Access Read More

Author(s): Milan Hait, Shivi Sharma, Leena Sahu, Sangeeta Sharma

DOI:         Access: Open Access Read More

Author(s): R. Samuel Selvaraj, S. Tamil Selvi

DOI:         Access: Open Access Read More

Author(s): Subha K., Kanimozhi K. ,Panneerselvam A.

DOI:         Access: Open Access Read More

Research Journal of Science and Technology (RJST) is an international, peer-reviewed journal, devoted to science and technology...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/2349-2988 


Recent Articles




Tags