The solid pseudopapillary tumor is a rare pancreatic neoplasm with many pseudonyms of uncertain to low malignant potential and predominant in young women under the age group of 20-36 years. This study was aimed to study of four such cases diagnosed on fine needle aspiration cytology (FNAC) in 2021-22 and its correlation with cytohistology. The image-guided FNAS was performed in these four patients prior to operation and later cytomorphological findings were evaluated by alcohol-fixed smears stained with Papanicolaou stain and diagnosis were made. Diagnosis were later confirmed by histology in the study which showed characteristic cytological features such as hypercellular smears with presence of abundant delicate papillary fragments, non-cohesive cells, heterogenic tumor cells with delicate folded nuclear membranes, and foamy macrophages in the background. Preoperative correct diagnosis of solid pseudopapillary tumor of pancreas is possible on FNAC and by doing so it helps in management of this surgically curable neoplasm.
Cite this article:
Prashant Kumar, Pooja Kumari. Study on Cytomorphology of Solid Pseudopapillary Tumor (SPT) in pancreas and its Differential Diagnosis. Research Journal of Science and Technology. 2023; 15(2):95-8. doi: 10.52711/2349-2988.2023.00016
Prashant Kumar, Pooja Kumari. Study on Cytomorphology of Solid Pseudopapillary Tumor (SPT) in pancreas and its Differential Diagnosis. Research Journal of Science and Technology. 2023; 15(2):95-8. doi: 10.52711/2349-2988.2023.00016 Available on: https://rjstonline.com/AbstractView.aspx?PID=2023-15-2-4
1. Klimstra DS, Wenig BM and Heffess CS (2000): Solid-pseudopapillary tumor of the pancreas: atypically cystic carcinoma of low malignant potential. Seminar Diagn Pathol, 17: 66-80.
2. Bapat KC, Pandit AA, Joshi AS, Vora IM (1992): Aspiration cytology of a papillary cystic neoplasm of pancreas (a case report). Indian J Cancer, 29:100-103.
3. Mohan H, Bal A, Punia RP and Attri AK (2006): Solid and cystic papillary epithelial neoplasm of the pancreas. J Postgrad Med, 52:141-142.
4. Naresh KN, Borges AM, Chinoy RF, Soman CS and Krishnamurthy SC (1995): Solid and papillary epithelial neoplasm of the pancreas: Diagnosis by fine needle aspiration cytology in four cases. Acta Cytol, 39: 489-493.
5. Pettinato G, Manivel JC, Ravetto C, Terracciano LM, Gould EW, Di Tuoro A (1992): Papillary cystic tumor of the pancreas: A clinicopathologic study of 20 cases with cytologic, immunohistochemical, ultrastructural and flow cytometric observations and a review of the literature. Am J Clin Pathol, 98: 478-488.
6. Mendonça ME, Bivar-Weinholtz J and Soares J (1991): Fine needle aspiration cytology of solid and papillary epithelial neoplasm of the pancreas. Acta Cytol, 35: 258-260.
7. Frantz VE (1959): Tumors of the pancreas. In: Anonymous atlas of tumor pathology. Washington DC: Armed Forces Institute of Pathology, pp 32-33.
8. Mendelsohn G (1992): Papillary cystic tumor of the pancreas: An enigma. Am J Clin Pathol, 98: 476-477.
9. Bondeson L, Bondeson AG, Genell S, Lindholm K and Thorstenson S (1984): Aspiration cytology of a rare solid and papillary epithelial neoplasm of the pancreas. Light and electronmicroscopic study of study of a case. Acta Cytol, 28: 605-609.
10. Pettinato G, Di Vizio D, Manivel JC, Pambuccian SE, Somma P and Insabato L (2002): Solid-pseudopapillary tumor of the pancreas: a neoplasm with distinct and highly characterstic cytological features. Diagn Cytopathol, 27:325-334.
11. Geener KJ, Feroze M, Geetha K and Jacob AJ (2002): Papillary cystic tumor of pancreas-report of two cases. Indian J Pathol Microbiol, 45: 99-101.
12. Jayaram G, Chaturvedi KU, Jindal RK, Venugopal S and Kapoor R (1990): Papillary cystic neoplasm of pancreas: Report of a case diagnosed by fine needle aspiration cytology. Acta Cytol, 34: 429-433.
13. Cappellari JO, Geisinger KR, Albertson DA, Wolfman NT and Kute TE (1990): Malignant papillatycystic tumor of the pancreas. Cancer, 66: 193-198.
14. Bardales RH, Centeno B, Mallery JS, Lai R, Pochapin M and Guiter G (2004): Endoscopic ultrasound-guided fine-needle aspiration cytology diagnosis of solid-pseudopapillary tumor of the pancreas: a rare neoplasm of elusive origin but characteristic cytomorphologic features. Am J Clin Pathol, 121:654-62.
15. Leiman G (2005): Pancreas, biliary tract and intraabdominal organs (In: Orell SR, Sterrett GF, Whitaker D editors: Fine needle aspiration cytology). Elsevier, pp 322-324.