Author(s):
Ahir Hemini Mukeshbhai, Anuradha P. Prajapati, Sachin B. Narkhede, Shailesh Luhar
Email(s):
hemiahir121@gmail.com
DOI:
10.52711/2349-2988.2025.00004 
Address:
Ahir Hemini Mukeshbhai¹*, Anuradha P. Prajapati, Sachin B. Narkhede, Shailesh Luhar
Department of Pharmaceutics, Smt. BNB Swaminarayan Pharmacy College, Gujarat Technological University, Salvav, Vapi, Gujarat, India, 396191.
*Corresponding Author
Published In:
Volume - 17,
Issue - 1,
Year - 2025
ABSTRACT:
Quality therapy has revolutionized the field of regenerative medication, advertising phenomenal potential for repairing or supplanting harmed tissues and organs. This comprehensive audit gives an in-depth examination of quality treatment advances and their applications in regenerative medication, highlighting current progresses, challenges, and future directions. We dig into the essential standards of quality treatment, counting viral and non-viral vector advances, quality altering apparatuses such as CRISPR/Cas9, and quality conveyance frameworks. The survey investigates the crossing point of quality treatment with tissue designing, organ recovery, and cell treatment, emphasizing the potential for synergistic approaches. Recent breakthroughs in quality treatment are examined, counting the improvement of novel vectors, improved quality expression direction, and moved forward focusing on techniques. The audit too addresses determined challenges, such as vector harmfulness, immunogenicity, and scalability. The clinical potential of quality treatment in treating different maladies is inspected, counting hereditary clutters, cancer, cardiovascular illness, and neurological conditions. We analyze the current scene of quality treatment clinical trials and progressing inquire about activities.
Cite this article:
Ahir Hemini Mukeshbhai, Anuradha P. Prajapati, Sachin B. Narkhede, Shailesh Luhar. Gene Therapy for Regenerative Medicine: Advances and Challenges. Research Journal of Science and Technology. 2025; 17(1):31-4. doi: 10.52711/2349-2988.2025.00004
Cite(Electronic):
Ahir Hemini Mukeshbhai, Anuradha P. Prajapati, Sachin B. Narkhede, Shailesh Luhar. Gene Therapy for Regenerative Medicine: Advances and Challenges. Research Journal of Science and Technology. 2025; 17(1):31-4. doi: 10.52711/2349-2988.2025.00004 Available on: https://rjstonline.com/AbstractView.aspx?PID=2025-17-1-4
4. REFERENCES:
1. http://www.isscr.org/public Stem cell information for the public from the International Society for Stem Cell Research (ISSCR).
2. http://www.stemcellresearclinews.com A commercial, online newsletter that features stories about stem cells of all types.
3. Soria et al., (2000). Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes.
4. Franke, W. W., Borrmann, C. M., Grund, C. and Pieperhoff, S. The area composite of adhering junctions connecting heart muscle cells of vertebrates: Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins. Eur J Cell Biol. 2006; 85: 69-82.
5. Schwendeman, S.; Costantino, H. R.; Gupta, R. K.; Langer, R. In Controlled Drug Delivery: Challenges and Strategies; Park, K., Ed.; American Chemical Society: Washington, DC 1997: 229-267.
6. Kumar, D. S., Banji, D., Madhavi, B., Bodanapu, V., Dondapati, S., Sri, A. P. International Journal of Pharmacy and Pharmaceutical Sciences. 2009; 1: 8-16.
7. Rantam, Fedik and Nugraha, Alexander and Mahyudin, Ferdiansyah and Purwati, Purwati and Bumi, Candra and Susilowati, Helen and Hendrianto, Eryk and Utomo, Dwikora and Suroto, Heri and Sumartono, Christrijogo and Setiawati, Rosy and Prakoeswa, Cita and Indramaya, Diah. A Potential Differentiation of Adipose and Hair Follicle-derived Mesenchymal Stem Cells to Generate Neurons Induced with EGF, FGF, PDGF and Forskolin. Research Journal of Pharmacy and Technology. 2020; 13: 275. doi: 10.5958/0974-360X.2020.00056.6.
8. Nugraha AP, Rezkita F, Puspitaningrum MS, Luthfimaidah MS, Narmada IB, Prahasanti C, et al. Gingival Mesenchymal Stem Cells and Chitosan Scaffold to Accelerate Alveolar Bone Remodelling in Periodontitis: A Narrative Review. Research J. Pharm. and Tech. 2020; 13(5). doi: 10.5958/0974-360X.2020.00446.1
9. Nugraha AP, Ihsan IS, Dinaryant A, Hendrianto E, Susilowati H, Prasetyo EP, et al. Cobalt (II) Chloride in Enhancing Hypoxia Inducible Factor-1α Expression of Gingival Derived Mesenchymal Stem Cells in Vitro. Research J. Pharm. and Tech. 2021; 14(5): 2639-2642. doi: 10.52711/0974-360X.2021.00465
10. Kirsti Uusi-Rasi, Saija Karinkanta, Kari Tokola, Pekka Kannus, Harri Sievänen, Bone Mass and Strength and Fall-Related Fractures in Older Age. Journal of Osteoporosis. 2019; 2019: 1-6. doi: 10.1155/2019/5134690.
11. Dr. Ashutosh Tiwari (2014) Sources of Stem Cells, (INTERNET) Available From DOI No:O<https://www.slideshare.net/ drashutoshtiwari/ Stem Cell-Therapy-36963348>,
12. Balakrishnan B, R Jayandharan G. Basic biology of adeno-associated virus (AAV) vectors used in gene therapy. Current Gene Therapy. 2014 Apr 1; 14(2): 86-100.
13. Samulski RJ, Muzyczka N. AAV-mediated gene therapy for research and therapeutic purposes. Annual Review of Virology. 2014 Sep 29; 1(1): 427-51.
14. Kay MA, Glorioso JC, Naldini L. Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nature Medicine. 2001 Jan; 7(1): 33-40.
15. Giacca M, Zacchigna S. Virus-mediated gene delivery for human gene therapy. Journal of Controlled Release. 2012 Jul 20; 161(2): 377-88.