Author(s): Kranti. M. Barbole, Bhakti. Y. Sabale, Gayatri. S. Pawar, Priyanka. K. Shinde


DOI: 10.52711/2349-2988.2024.00015   

Address: Kranti. M. Barbole1, Bhakti. Y. Sabale1, Gayatri. S. Pawar1, Priyanka. K. Shinde2
1Student, JBVP Vidya Niketan College of Pharmacy, Lakhewadi.
2Assistant Professor of Pharmacognosy, JBVP Vidya Niketan College of Pharmacy, Lakhewadi.
*Corresponding Author

Published In:   Volume - 16,      Issue - 1,     Year - 2024

Background: Mycobacterium tuberculosis, which is responsible for tuberculosis, has become resistant to a majority of the existing antimicrobial treatments. As a result, effectively treating all tuberculosis patients has become challenging, and it's anticipated that cases of drug-resistant M. tuberculosis causing tuberculosis will rise globally. This emphasizes the pressing need for prompt detection and the creation of novel antimicrobial options to fight M. tuberculosis. When some germs become resistant to many medicines, it's hard to cure the infections they cause. It's important to look into different options for fighting TB. That's why studying natural plants, like garlic (Allium sativum), to learn about their safety and ability to fight microbes, including its various biological properties such as anti-tumour, anti-hyperlipidemic, and antimicrobial effects, is necessary. Allium sativum holds promise for creating new treatment options. Involving traditional healers in TB healthcare could aid in delivering garlic extracts to patients. Tuberculosis is a significant global cause of death, particularly when combined with AIDS. This contagious pulmonary disease spreads readily, especially in overcrowded and impoverished conditions. Garlic is a strong way to fight against infections from lots of different germs like bacteria, fungi and viruses. Using garlic to combat MDR-TB could have significant implications for public health.

Cite this article:
Kranti. M. Barbole, Bhakti. Y. Sabale, Gayatri. S. Pawar, Priyanka. K. Shinde. A Review: The Potential Role of Garlic (Allium sativum L.) against Tuberculosis: Multi Drug-Resistance. Research Journal of Science and Technology. 2024; 16(1):97-3. doi: 10.52711/2349-2988.2024.00015

Kranti. M. Barbole, Bhakti. Y. Sabale, Gayatri. S. Pawar, Priyanka. K. Shinde. A Review: The Potential Role of Garlic (Allium sativum L.) against Tuberculosis: Multi Drug-Resistance. Research Journal of Science and Technology. 2024; 16(1):97-3. doi: 10.52711/2349-2988.2024.00015   Available on:

1.    The potential role of garlic (Allium sativum) against the multi-drug resistant tuberculosis pandemic: a review
2.    Chemical Datasets, Antioxidant, Free Radicals Scavenger activities estimate in Aqueous Garlic (Allium sativum) extract, Research Journal of Pharmacy and Technology
4.    Rohan R. Vakhariya, Swati Talokar, Archana R. Dhole, S.K. Mohite, C.S. Magdum, Comparative Standardization Study of Two Marketed Shatavari Churna Formulation. Asian Journal of Pharmaceutical Analysis. 2016; 6 (1): 1-6.
5.    Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.) : A Review
6.    Cohen KA, et al. Evolution of extensively drug-resistant tuberculosis over four decades: whole genome sequencing and dating analysis of Mycobacterium tubercu by losis isolates from KwaZulu-Natal. PLoS Med. 2015; 12(9):e1001880. doi: 10.1371/journal.pmed.1001880.  
7.    Velayati AA, et al. The emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in Iran. Chest. 2009; 136(2): 420–425. doi: 10.1378/chest.08-2427.   
8.    Anti-mycobacterial activity of garlic (Allium sativum) against multi-drug resistant and reference strain of Mycobacterium tuberculosis
9.    Gupta VK, Shukla C, Bisht GR, Saikia D, Kumar S, Thakur RL. Detection of anti-tuberculosis activity in some folklore plants by radiometric BACTEC assay. Lett Appl Microbiol. 2004; 52: 33– 40.  
10.    Garlic Inhibits Tuberculosis Bacteria (possibly by Jamming Bacteria Twitter Feed)
11.    Bhattacharya (1976); Thomson and Ali (2003); Hosseini and Hosseinzadeh (2015)  
12.    Singh R., Singh K. Garlic: a spice with wide medicinal actions. Journal of Pharmacognosy and Phytochemistry. 2019; 8(1): 1349–1355.  
13.    Jang HJ, Lee HJ, Yoon DK, Ji DS, Kim JH, Lee CH. Antioxidant and antimicrobial activities of fresh garlic and aged garlic by-products extracted with different solvents. Food Sci Biotechnol. 2018; 27: 219–25. doi:10.007/s10068-017-0246-4
14.    Medicinal and therapeutic properties of garlic, garlic essential oil, and garlic-based snack food: An dated review
15.    Garlic extracts have a broad antibacterial spectrum that includes gram-negative and gram positive microorganisms
16.    Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs
17.    Choo S, Chin VK, Wong EH, Madhavan P, Tay ST, Yong PVC, et al. Antimicrobial properties of allicin used alone or in combination with other medications. Folia Microbiol. 2020; 65: 451–65. doi: 10.1007/s12223-020-00786-5
18.    Guo, Y.J. Experimental study on the optimization of extraction process of garlic oil and its antibacterial effects. Afr. J. Tradit. Complement. Altern. Med. 2014; 11: 411–414.
19.    Liu, Q.; Meng, X.; Li, Y.; Zhao, C.N.; Tang, G.Y.; Li, S.; Gan, R.Y.; Li, H.B. Natural products for the prevention and management of Helicobacter pylori infection. Compr. Rev. Food Sci. F. 2018; 17: 937–952.
20.    Liu, Q.; Meng, X.; Li, Y.; Zhao, C.N.; Tang, G.Y.; Li, H.B. Antibacterial and antifungal activities of spices. Int. J. Mol. Sci. 2017; 18: 1283.
21.    Chemistry of Fluoroquinones in The Management of Tuberculosis (TB): An Overview, Sourabh D Jain, Arun Kumar Gupta, Asian Journal of Pharmaceutical Research
22.    Fratianni, F.; Riccardi, R.; Spigno, P.; Ombra, M.N.; Cozzolino, A.; Tremonte, P.; Coppola, R.; Nazzaro, F. Biochemical characterization and antimicrobial and antifungal activity of two endemic varieties of garlic (Allium sativum L.) of the campania region, southern Italy. J. Med. Food. 2016, 19: 686–691.
24.    Diretto, G.; Rubio-Moraga, A.; Argandona, J.; Castillo, P.; Gomez-Gomez, L.; Ahrazem, O. Tissue-specific accumulation of sulfur compounds and saponins in different parts of garlic cloves from purple and white ecotypes. Molecules. 2017; 22: 1359.
25.    Szychowski, K.A.; Rybczynska-Tkaczyk, K.; Gawel-Beben, K.; Swieca, M.; Karas, M.; Jakubczyk, A.; Matysiak, M.; Binduga, U.E.; Gminski, J. Characterization of active compounds of different garlic (Allium sativum L.) cultivars. Pol. J. Food Nutr. Sci. 2018; 68:73–81.
26.    Bradley, J.M.; Organ, C.L.; Lefer, D.J. Garlic-derived organic polysulfides and myocardial protection. J. Nutr.  2016; 146: 403S–409S.
27.    Wang, Y.C.; Guan, M.; Zhao, X.; Li, X.L. Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice. Pharm. Biol. 2018; 56: 325–332.
28.    Yoo, D.Y.; Kim, W.; Nam, S.M.; Yoo, M.; Lee, S.; Yoon, Y.S.; Won, M.H.; Hwang, I.K.; Choi, J.H. Neuroprotective effects of Z-ajoene, an organosulfur compound derived from oil-macerated garlic, in the gerbil hippocampal CA1 region after transient forebrain ischemia. Food Chem. Toxicol. 2014; 72: 1–7.
29.    Kodera, Y.; Ushijima, M.; Amano, H.; Suzuki, J.; Matsutomo, T. Chemical and biological properties of S-1-propenyl-l-cysteine in aged garlic extract. Molecules. 2017; 22: 570.
30.    Yoo, M.; Lee, S.; Kim, S.; Hwang, J.B.; Choe, J.; Shin, D. Composition of organosulfur compounds from cooland warm-type garlic (Allium sativum L.) in Korea. Food Sci. Biotechnol. 2014; 23:337–344.
31.    Mansingh, D.P.; Dalpati, N.; Sali, V.K.; Vasanthi, A.H.R. Alliin the precursor of allicin in garlic extract mitigates proliferation of gastric adenocarcinoma cells by modulating apoptosis. Pharmacogn. Mag. 2018; 14: S84–S91.
32.    Torres-Palazzolo, C.; Ramirez, D.; Locatelli, D.; Manucha, W.; Castro, C.; Camargo, A. Bioaccessibility and permeability of bioactive compounds in raw and cooked garlic. J. Food Compos. Anal. 2018; 70” 49–53.
33.    Block, Naganathan,  Putman, and Zhao, 1993; Horníčková, Kubec, Cejpek, Velíšek, Ovesná, and Stavelíková,  2010.
34.    Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review
35.    Reiter J, Levina N, Van der Linden M, Gruhlke M, Martin C, Slusarenko AJ. Diallylthiosulfinate (Allicin), a volatile antimicrobial from garlic (Allium sativum), kills human lung pathogenic bacteria, including MDR strains, as a vapor. Molecules. 2017; 22(10): 1711.
36.    Formulation and Evaluation of Antifungal Soap of Garlic Oil, Rutuja R. Shah, Rohan R. Vakhariya, Asian Journal of Pharmaceutical Research
37.    Dwivedi VP, Bhattacharya D, Singh M, Bhaskar A, Kumar S, Fatima S, et al. Allicin enhances antimicrobial activity of macrophages during Mycobacterium tuberculosis infection. Journal of Ethnopharmacology. 2019; 243: 11163.
38.    Deoghare S. Bedaquiline: a new drug approved for treatment of multidrug-resistant tuberculosis. Indian Journal of Pharmacology. 2013; 45(5): 536.
39.    Li WR, Ma YK, Shi QS, Xie XB, Sun TL, Peng H, et al. Diallyl disulfide from garlic oil inhibits Pseudomonas aeruginosa virulence factors by inactivating key quorum sensing genes. Applied Microbiology and Biotechnology. 2018; 102(17): 7555-64.
40.    Fatima S, Kumari A, Das G, Dwivedi VP. Tuberculosis vaccine: A journey from BCG to present. Life Sciences. 2020: 117594
41.    Majewski M. Allium sativum: facts and myths regarding human health. Roczniki Państwowego Zakładu Higieny. 2014; 65(1).
42.    Curtis H, Noll U, Störmann J, Slusarenko AJ. Broadspectrum activity of the volatile phytoanticipin allicin in extracts of garlic (Allium sativum L.) against plant pathogenic bacteria, fungi and Oomycetes. Physiological and Molecular Plant Pathology. 2004; 65(2): 79-89.
43.    Fujisawa H, Watanabe K, Suma K, Origuchi K, Matsufuji H, Seki T, Ariga T. Antibacterial potential of garlic-derived allicin and its cancellation by sulfhydryl compounds. Bioscience, Biotechnology, and Biochemistry. 2009; 73(9): 1948-55.
44.    Marchese A, Barbieri R, Sanches-Silva A, Daglia M, Nabavi SF, Jafari NJ, Izadi M, Ajami M, Nabavi SM. Antifungal and antibacterial activities of allicin: A review. Trends in Food Science and Technology. 2016; 52: 49- 56
45.    Borlinghaus J, Albrecht F, Gruhlke MC, Nwachukwu ID, Slusarenko AJ. Allicin: chemistry and biological properties. Molecules. 2014; 19(8): 12591-618.
46.    Vathsala PG, Murthy PK. Immunomodulatory and antiparasitic effects of garlic–arteether combination via nitric oxide pathway in Plasmodium berghei-infected mice. Journal of Parasitic Diseases. 2020; 44(1): 49- 61.
47.    Peltzer K, Mngqundaniso N. Patients. Consulting traditional health practioners in the context of HIV/AIDS in urban areas in Kwazulu-Natal,  South Africa. Afr J Tradit Complement Altern Med. 2008; 5(4): 370-9.
48.    Willkinson D, Gcabashe L, Lurie M. Traditional healers as tuberculosis treatment supervisors: precedent and potential. Int J Tuberc Lung Dis. 1999; 3(9): 838-42.
49.    Colvin M, Gumede L, Grimwadw K, Maher D, Willkinson D. Contribution of traditional healers to a rural tuberculosis control programme in Hlabisa, South Africa. Int J Tuberc Lung Dis. 2003; 7(9 Suppl. 1): 86-91.
50.    Brouwer JA, Boeree MJ, Kager P, Varkevisser CM, Harries AD. Traditional healers and pulmonary tuberculosis in Malawi. Int J Tuberc Lung Dis 1998; 2(3): 231-4.
51.    UNAIDS. Collaboration with traditional healers in HIV/ AIDS prevention and care in sub-Saharan Africa. A literature review. Geneva: UNAIDS; 2000.
52.    UNAIDS. Ancient remedies, new disease: involving traditional healers in increasing access to AIDS care and prevention in East Africa. Geneva: UNAIDS; 2002.

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