Research Journal of Science and Technology

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2349-2988 (Online)
0975-4393 (Print)


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Estimation of Almotriptan malate in tablets by sensitive Visible Spectrophotometric method

Author(s): B. Kalyana Ramu, M. Syam Bab, U. Viplava Prasad, P. Konda Babu

Email(s): kalyanaramu23566@gmail.com , msyambab@gmail.com

DOI: 10.5958/2349-2988.2019.00012.3   

Address: B. Kalyana Ramu1*, M. Syam Bab*2, U. Viplava Prasad2 P. Konda Babu3
1Department of Chemistry, Maharajah’s College (Aided and Autonomous), Vizianagaram-535002 (AP) India.
2Department of Organic Chemistry and Analysis of Foods Drugs and Water Laboratories, School of Chemistry, Andhra University, Visakhapatnam-530003, Andhra Pradesh (India)
3Department of Statistics, Maharajah’s College (Aided and Autonomous), Vizianagaram-535002 (AP) India.
*Corresponding Author

Published In:   Volume - 11,      Issue - 1,     Year - 2019

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ABSTRACT:
A simple, sensitive indirect visible spectrophotometric method has been developed for the estimation of almotriptan malate either in bulk or tablet dosage forms. The method is based on the oxidation of drug with excess N-Bromo succinimide and determining the unreacted NBS with reagents PMAP-SA by spectrophotometrically at 520nm Beer’s law obeyed in the concentration range of 4-20 µg/ml. No interference was observed from the usually existing additives in pharmaceutical formulations and the applicability of the method was examined by analyzing AXERT tablets containing AM. The statistical data indicates the accuracy, reproducibility and the precision of the proposed method.


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Cite this article:
B. Kalyana Ramu, M. Syam Bab, U. Viplava Prasad, P. Konda Babu. Estimation of Almotriptan malate in tablets by sensitive Visible Spectrophotometric method. Research J. Science and Tech. 2019; 11(1):77-81. doi: 10.5958/2349-2988.2019.00012.3


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Research Journal of Science and Technology (RJST) is an international, peer-reviewed journal, devoted to science and technology. The aim of RJST is to increase the impact of technological research both in academia and industry, with strong emphasis on quality and originality. RJST publishes Original Research Articles, Short Communications, Review Articles in all areas of Science and Technology.
Research Journal of Science and Technology (RJST) is published every year in last week of February, April, June, August, October and December from Raipur. From January 2013, is Quarterly and shall be published every year in last week of March, June, September and December.    
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