Author(s): Rahul K. Godge, Ganesh S. Shinde, Shraddha Joshi

Email(s): Rahul_godge@rediffmail.com

DOI: 10.5958/2349-2988.2019.00008.1   

Address: Rahul K. Godge*, Ganesh S. Shinde, Shraddha Joshi
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, India
*Corresponding Author

Published In:   Volume - 11,      Issue - 1,     Year - 2019


ABSTRACT:
A simple, rapid, precise, accurate RP-HPLC method has been developed and validated to estimate Saxagliptin hydrochloride and Dapagliflozin in bulk and in dosage form. The samples were eluated Grace C18 (250mm x 4.6 ID, Particle size: 5micron with mobile phase Methanol: water (pH adjusted to 3 with potassium dihydrogen orthophosphate) (80:20) at wavelength 225nm. A good linear response was obtained in the range from 10-50µg/mL for Saxagliptin hydrochloride and Dapagliflozin. The method was quantitatively evaluated in terms of linearity, precision, accuracy (recovery), selectivity and robustness as per USP guideline.


Cite this article:
Rahul K. Godge, Ganesh S. Shinde, Shraddha Joshi. Simultaneous Estimation and Validation of Dapagliflozin and Saxagliptin in Bulk Drug and Dosage Form by RP-HPLC. Research J. Science and Tech. 2019; 11(1):59-63. doi: 10.5958/2349-2988.2019.00008.1


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DOI: 10.5958/2349-2988 


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