Author(s): Akash Shelke, Someshwar Mankar, Mahesh Kolhe

Email(s): Shelkeakash2014@gmail.com

DOI: 10.52711/2349-2988.2021.00015   

Address: Akash Shelke*, Someshwar Mankar, Mahesh Kolhe
Department of Quality Assurance Techniques, Prvara Rural College of Pharmacy, Pravaranagar, Tal- Rahata, Dist- Ahmednagar 413736, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 2,     Year - 2021


ABSTRACT:
Objective of the present work is to develop and validate a simple, cost effective, sensitive and fast HPLC method for the analysis of Secnidazole. A Merck-Hitachi HPLC system with Peerless Basic C18 (50mm x 4.6mm x 3µm) column is employed for the analysis using buffer: methanol (80:20, v/v) as mobile phase. Signal from Secnidazole is detected at 310nm by UV Spectrophotometer. The proposed method is fully validated and found to be linear over a workable drug concentration, accurate, precise and robust. This fast and inexpensive method is suitable for research laboratories as well as for quality control analysis in pharmaceutical industries.


Cite this article:
Akash Shelke, Someshwar Mankar, Mahesh Kolhe. Development and Validation of RP-HPLC Method for estimation of Secnidazole in API and Pharmaceutical Dosage Form. Research Journal of Science and Technology. 2021; 13(2):100-4. doi: 10.52711/2349-2988.2021.00015

Cite(Electronic):
Akash Shelke, Someshwar Mankar, Mahesh Kolhe. Development and Validation of RP-HPLC Method for estimation of Secnidazole in API and Pharmaceutical Dosage Form. Research Journal of Science and Technology. 2021; 13(2):100-4. doi: 10.52711/2349-2988.2021.00015   Available on: https://rjstonline.com/AbstractView.aspx?PID=2021-13-2-6


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3.    Vishal Singh, Kritarth Nama; Secnidazole Oral Granules: A Novel Drug Formulation and an Effective Alternative in Treatment of Bacterial Vaginosis; International Journal of Innovative Research and Growth 2018;3(4).
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8.    Rajan V. Rele, Sandip P. Patil; Development of Analytical method by RP-HPLC Technique for determination of Secnidazole in API and Pharmaceutical Dosage Form; Research J. Pharm. and Tech. 2019;12(10): -4799.
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