Author(s):
Priya Patel, Krishna Butani, Kruti Jadwani
Email(s):
patelpriyav@gmail.com
DOI:
10.52711/2349-2988.2023.00023 
Address:
Priya Patel*, Krishna Butani, Kruti Jadwani
Department of Pharmaceutical science, Saurashtra University, Rajkot-360005, Gujarat, India.
*Corresponding Author
Published In:
Volume - 15,
Issue - 3,
Year - 2023
ABSTRACT:
Pharmaceutical industries are involving day by day. New inventions in medicines are changing human’s life and provides better medications. But the role of pharmacy is not limited to the earth, pharmacy sector can also benefits the space sector by providing effective medications to the astronauts in the space travel. But formulating the medicines for the space environment is not easy compared to that on the earth. Microgravity produces many difficulties in the stability of the drug products and is also affect the functionality of drugs in the body. Short space missions may not produce that much problem but when there is a deep space missions the health of astronauts become major challenge. This problem creates a need for novel drug technologies to overcome these problems. In this article a brief introduction of the microgravity related problems to the astronauts and to the drugs, approaches to formulate medicines for space travel and a short information about Astro pharmacy
Cite this article:
Priya Patel, Krishna Butani, Kruti Jadwani. Universe of space medicine: Emerging Technologies in field of Pharmacy. Research Journal of Science and Technology. 2023; 15(3):140-4. doi: 10.52711/2349-2988.2023.00023
Cite(Electronic):
Priya Patel, Krishna Butani, Kruti Jadwani. Universe of space medicine: Emerging Technologies in field of Pharmacy. Research Journal of Science and Technology. 2023; 15(3):140-4. doi: 10.52711/2349-2988.2023.00023 Available on: https://rjstonline.com/AbstractView.aspx?PID=2023-15-3-3
REFERENCES:
1. Tavassoli, M., Medical problems of space flight. The American Journal of Medicine, 1986. 81(5): p. 850-854.
2. Williams, D., et al., Acclimation during space flight: effects on human physiology. CMAJ, 2009. 180(13): p. 1317-1323.
3. Pillay, V., et al., Three-Dimensional Printing (3DP) for Space Pharmaceuticals, in Handbook of Space Pharmaceuticals. 2022, Springer. p. 221-258.
4. Barger, L.K., et al., Prevalence of sleep deficiency and use of hypnotic drugs in astronauts before, during, and after spaceflight: an observational study. The Lancet Neurology, 2014. 13(9): p. 904-912.
5. Crucian, B., et al., Incidence of clinical symptoms during long-duration orbital spaceflight. International Journal of General Medicine, 2016. 9: p. 383.
6. Mehta, P. and D. Bhayani, Impact of space environment on stability of medicines: challenges and prospects. Journal of Pharmaceutical and Biomedical Analysis, 2017. 136: p. 111-119.
7. Thirsk, R., et al., The space-flight environment: the International Space Station and beyond. Cmaj, 2009. 180(12): p. 1216-1220.
8. Patel, J. and A. Patel, Nano drug delivery systems for space applications, in Handbook of Space Pharmaceuticals. 2022, Springer. p. 113-134.
9. Grattoni, A., et al., Nanotechnologies and regenerative medical approaches for space and terrestrial medicine. Aviation, Space, and Environmental Medicine, 2012. 83(11): p. 1025-1036.
10. Anglin, E.J., et al., Porous silicon in drug delivery devices and materials. Advanced Drug Delivery Reviews, 2008. 60(11): p. 1266-1277.
11. Tanaka, T., et al., Sustained small interfering RNA delivery by mesoporous silicon particles. Cancer Research, 2010. 70(9): p. 3687-3696.
12. Knežević, N.Ž. and G.N. Kaluđerović, Silicon-based nanotheranostics. Nanoscale, 2017. 9(35): p. 12821-12829.
13. Klöck, G., et al., Biocompatibility of mannuronic acid-rich alginates. Biomaterials, 1997. 18(10): p. 707-713.
14. Temenoff, J.S. and A.G. Mikos, Injectable biodegradable materials for orthopedic tissue engineering. Biomaterials, 2000. 21(23): p. 2405-2412.
15. Aswin SK, Jothishwar S, Nayagam P, Priya G. Scaffolds for biomolecule delivery and controlled release-A Review. Research Journal of Pharmacy and Technology. 2018;11(10):4719-30.
16. Widyaputra S, Sitam S, Suherna I, Fitri AD, Rachman A. Comparison of bone regeneration in hADMSC versus hUCBMSC with hBMMSC as a reference: A literature review of potential bone regeneration. Research Journal of Pharmacy and Technology. 2021;14(4):1993-8.
17. Sambu, S., et al., RGDS-fuctionalized alginates improve the survival rate of encapsulated embryonic stem cells during cryopreservation. Cryoletters, 2011. 32(5): p. 389-401.
18. Sambu, S., et al., Predicting the survival rate of mouse embryonic stem cells cryopreserved in alginate beads. Proceedings of the Institution of Mechanical Engineers, Part H. Journal of Engineering in Medicine, 2011. 225(11): p. 1092-1107.
19. Fu, Q., et al., Bioactive glass scaffolds for bone tissue engineering: state of the art and future perspectives. Materials Science and Engineering: C, 2011. 31(7): p. 1245- 1256.
20. Hu, Q., et al., Preparation and characterization of biodegradable chitosan/hydroxyapatite nanocomposite rods via in situ hybridization: a potential material as internal fixation of bone fracture. Biomaterials, 2004. 25(5): p. 779-785.
21. Akhter, S., et al., Gold nanoparticles in theranostic oncology: current state-of-the-art. Expert Opinion on Drug Delivery, 2012. 9(10): p. 1225-1243.
22. Saudagar RB, Kanchan TM. A Review on Gold Nanoparticles. Asian J. Pharm. Res. 2016 Jan;6(1):45-8.
23. Rao CV, Manimaran V, Damodharan N. Review on Methods, Applications and Role of gold nano particles in Cancer Therapy. Research Journal of Pharmacy and Technology. 2020 Aug 12;13(8):3963-8.
24. Bhumkar, D.R., et al., Chitosan reduced gold nanoparticles as novel carriers for transmucosal delivery of insulin. Pharmaceutical Research, 2007. 24(8): p. 1415-1426.
25. Ragno, G., et al., Photostabilization of 1, 4-dihydropyridine antihypertensives by incorporation into β-cyclodextrin and liposomes. Journal of Nanoscience and Nanotechnology, 2006. 6(9-10): p. 2979-2985.
26. Awad, A., et al., Reshaping drug development using 3D printing. Drug Discovery Today, 2018. 23(8): p. 1547-1555.
27. Pietrzak, K., A. Isreb, and M.A. Alhnan, A flexible-dose dispenser for immediate and extended-release 3D printed tablets. European Journal of Pharmaceutics and Biopharmaceutics, 2015. 96: p. 380-387.
28. Lee, B.K., et al., Fabrication of drug-loaded polymer microparticles with arbitrary geometries using a piezoelectric inkjet printing system. International Journal of Pharmaceutics, 2012. 427(2): p. 305-310.
29. NASA, 2020. An Astropharmacy [Internet]. Available from: 1. https://www.nasa.gov/directorates/spacetech/niac/2020_Phase_I_Phase_II/Astropharmacy/ (last accessed 5 December 2022).